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Current Oncology Reports

, 17:53 | Cite as

The Role of Radiotherapy After Radical Prostatectomy in Patients with Prostate Cancer

  • Giorgio GandagliaEmail author
  • Cesare Cozzarini
  • Alexandre Mottrie
  • Alberto Bossi
  • Nicola Fossati
  • Francesco Montorsi
  • Alberto Briganti
Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Genitourinary Cancers

Abstract

A non-negligible proportion of prostate cancer (PCa) patients undergoing radical prostatectomy (RP) harbors aggressive disease. These individuals are at higher risk of experiencing recurrence after surgery. Results from prospective, randomized trials support the efficacy of adjuvant radiotherapy (aRT) on cancer control in selected patients with adverse disease features at RP. However, only one of these randomized trials found a significant benefit of aRT on survival. Although such a level of evidence is not currently available for salvage RT, retrospective studies demonstrated that this approach leads to excellent outcomes if administered at the earliest sign of PSA recurrence. Prognostic models might help clinicians in identifying patients who would benefit the most from adjuvant and/or salvage RT. This individualized approach would allow sparing the risk of short- and long-term toxicity in a substantial proportion of patients. Nonetheless, results from randomized trials are still awaited to compare the efficacy of (early) salvage and aRT.

Keywords

Prostate cancer Radical prostatectomy Salvage radiotherapy Multi-modal treatment Adjuvant radiotherapy Androgen deprivation therapy 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Giorgio Gandaglia, Cesare Cozzarini, Alexandre Mottrie, Alberto Bossi, Nicola Fossati, Francesco Montorsi, and Alberto Briganti declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Giorgio Gandaglia
    • 1
    • 2
    Email author
  • Cesare Cozzarini
    • 3
  • Alexandre Mottrie
    • 2
    • 4
  • Alberto Bossi
    • 5
  • Nicola Fossati
    • 1
  • Francesco Montorsi
    • 1
  • Alberto Briganti
    • 1
  1. 1.Unit of Urology/Division of Oncology, URIIRCCS Ospedale San RaffaeleMilanItaly
  2. 2.OLV Vattikuti Robotic Surgery InstituteMelleBelgium
  3. 3.Department of RadiotherapyIRCCS Ospedale San RaffaeleMilanItaly
  4. 4.Department of UrologyOnze-Lieve-Vrouw HospitalAalstBelgium
  5. 5.Department of Radiation OncologyInstitut Gustave RoussyVillejuifFrance

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