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Current Oncology Reports

, 17:58 | Cite as

Targeting Signaling Transduction Pathways in Bladder Cancer

  • Phillip H. Abbosh
  • David J. McConkey
  • Elizabeth R. Plimack
Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Genitourinary Cancers

Abstract

Systemic therapy for urothelial carcinoma (UC) of the bladder has largely revolved around cytotoxic chemotherapy regimens. However, several recent clinical trials have explored the roles of targeted therapies which specifically inhibit signal transduction pathways. Simultaneously, a rationale for such therapies has come to the forefront of management of this disease because an overabundance of signaling pathways are genetically deranged as a result of point mutation or copy number alteration (CNA) as identified by several recent next generation sequencing (NGS) studies. Importantly, these derangements are found in all stages of disease, and therefore targeted therapies hold promise as a next step in the evolution of the medical management of both localized and metastatic UCC. We review the rationale for and progress in studying inhibition of signal transduction as a means of treatment of UCC.

Keywords

Bladder cancer Chemotherapy Mutation Copy number abnormality EGFR ERBB2 ERBB3 FGFR3 PIK3CA mTOR PTEN Sunitinib Pazopanib Erlotinib Cetuximab Everolimus Bevacizumab Dovitinib 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Phillip H. Abbosh has received compensation from the Advanced Individual Medicine for service as a consultant.

David J. McConkey has received research funding through a grant from AstraZeneca and has been issued a patent, filed by The University of Texas M.D. Anderson Cancer Center, for the method for identifying intrinsic subtypes of muscle-invasive bladder cancer.

Elizabeth R. Plimack has received clinical trial funding through grants from Pfizer, GlaxoSmithKline, Bristol Myers-Squibb, AstraZeneca, Eli Lilly, Merck, Dendreon, and Acceleron; has received compensation from Pfizer, GlaxoSmithKline, Novartis, Genentech, Bristol Myers-Squibb, Merck, Dendreon, and Astellas for service on advisory boards; and has been issued a patent, filed by Fox Chase Cancer Center, for the methods for screening muscle-invasive bladder cancer patients for neoadjuvant chemotherapy responsiveness.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Phillip H. Abbosh
    • 1
  • David J. McConkey
    • 2
    • 3
  • Elizabeth R. Plimack
    • 4
  1. 1.Department of Surgical Oncology, Division of Urologic OncologyFox Chase Cancer CenterPhiladelphiaUSA
  2. 2.Departments of Urology and Cancer BiologyUniversity of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.The University of Texas-Graduate School of Biomedical Sciences (GSBS) at HoustonHoustonUSA
  4. 4.Department of Medical OncologyFox Chase Cancer CenterPhiladelphiaUSA

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