Adjuvant Whole-Brain Radiotherapy Versus Observation after Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952-26001 Study
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Kocher M, Soffietti R, Abacioglu U, et al.: Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 2011, 29:134–141.
Rating •Of importance.
Introduction: Brain metastases are a frequent cause of morbidity and mortality in patients suffering from a variety of solid tumors. Surgery, radiosurgery, and whole-brain radiotherapy (WBRT) are the main treatment options. The role of adjuvant WBRT after complete surgical resection or radiosurgery remains controversial. The risk of long-term neurotoxicity and availability of effective salvage treatments [1, 2] are the main arguments against adjuvant WBRT.
Aim: The objective of this study was to investigate the role of adjuvant WBRT after either surgery or radiosurgery of a limited number of brain metastases from solid tumors, focusing on patients in good condition with stable systemic cancer.
Methods:Patients with one...
KeywordsBrain Metastasis Functional Independence Macroscopic Tumor Neurologic Death Curative Intent Treatment
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