Current Oncology Reports

, Volume 13, Issue 3, pp 206–215

Predictive and Prognostic Markers in Colorectal Cancer



Colorectal cancer (CRC) has a complex pathogenesis involving multiple sequential steps with accumulation of genetic alterations including mutations, gene amplification, and epigenetic changes. Treatment of CRC has undergone a paradigm shift over the past decade due in part to a better understanding of the biology of the disease and development of newer drugs including biologic agents. In the era of personalized medicine, it is attractive to investigate the molecular pathways leading to colorectal cancer tumorigenesis, thus raising the possibility of identifying novel therapeutic targets. It has intuitive appeal to hypothesize that biomarkers that have prognostic and/or predictive value are those that are intimately connected to the pathogenesis of CRC. In this article, we focus on prognostic and predictive markers in CRC that have a substantial body of data in support of their potential role in routine clinical practice.


Colorectal cancer Predictive marker Prognostic marker 18q MMR KRAS BRAF PIK3CA PTEN 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Hematology/Medical OncologyMedical College of WisconsinMilwaukeeUSA
  2. 2.GI Medical OncologyThe University of Texas M.D. Anderson Cancer Center, Faculty Center (FC 10.2004)HoustonUSA

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