Swing of the pendulum: Optimizing functional outcomes in larynx cancer
- First Online:
For years, total laryngectomy was the only treatment option for patients with intermediate to advanced laryngeal cancer. Over the past two decades, great progress has been made in the management of this disease, with multimodality approaches aimed at laryngeal preservation reshaping the treatment landscape. In the era of chemoradiation, greater focus and attention are now directed toward functional laryngeal preservation—not simply “organ preservation.” The continued development and integration of new treatment approaches, including organ preservation surgery (eg, transoral minimally invasive surgery of the head and neck, supracricoid partial laryngectomy), intensity-modulated radiotherapy, and targeted molecular therapies, offer the potential to improve clinical outcomes, function, and quality of life. Incorporation of these new approaches advances the concept of personalized medicine, with treatment strategies tailored to the circumstances and future of each patient.
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 3.Pignon JP, Bourhis J, Domenge C, Designé L: Chemotherapy added to locoregional treatment for head and neck squamouscell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 2000, 355:949–955.PubMedGoogle Scholar
- 4.Bourhis J, Amand C, Pignon JP; MACH-NC Collaborative Group: Update of MACH-NC (Meta-Analysis of Chemotherapy in Head and Neck Cancer) database focused on concomitant chemotherapy [ASCO abstract]. J Clin Oncol 2004, 22(14S):abstract 5505.Google Scholar
- 5.National Comprehensive Cancer Center Network: Clinical practice guidelines in oncology — v.1.2007: head and neck cancer. http://www.nccn.org/professionals/physician_gls/PDF/head-and-neck.pdf. Accessed December 2007.
- 14.Steiner W, Ambrosch P: Endoscopic Laser Surgery of the Upper Aerodigestive Tract with Special Emphasis on Cancer Surgery. Translated by Knappe MV. Stuttgart, Germany; New York, NY: Georg Thieme Verlag; 2000.Google Scholar
- 19.Steiner W, Martin A, Ambrosch P, et al.: Laser microsurgical treatment of pT2/#N0 carcinoma of the glottis: results of 301 cases. Presented at the 85th Annual Meeting of the American Broncho-Esophageal Association. May 14, 2005; Boca Raton, FL.Google Scholar
- 23.Zeitels SM, Hillman RE, Franco RA, Bunting GW: Voice and treatment outcome for phonosurgical management of early glottic cancer. Ann Otol Rhinol Laryngol 2002, 190(Suppl):3–20.Google Scholar
- 24.Weinstein GS, Laccourreye O, Brasnu D, Laccourreye H: Organ Preservation Surgery for Laryngeal Cancer. San Diego, CA: Singular; 2000.Google Scholar
- 37.Bonner J, Harari P, Giralt J, et al.: Improved preservation of larynx with the addition of cetuximab to radiation for cancers of the larynx and hypopharynx [abstract]. J Clin Oncol 2005, 23(16S):abstract 5533.Google Scholar
- 39.Cella DF: Manual for the Functional Assessment of Cancer Therapy (FACT) Measurement System (v.3). Chicago, IL: Rush Medical Center; 1994.Google Scholar