Current Oncology Reports

, Volume 7, Issue 5, pp 349–356

Linking KSHV to human cancer

  • Emily L. Wong
  • Blossom Damania
Article

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), has been linked to several malignancies in humans. KSHV is the etiologic agent associated with the development of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KSHV is a double-stranded DNA virus that has been classified as a gammaherpesvirus. Here, we review the association of KSHV with human cancer, viral genes that may potentially be involved in the neoplastic process, and current therapies used to treat KS, PEL, and MCD.

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Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Emily L. Wong
  • Blossom Damania
    • 1
  1. 1.Lineberger Comprehensive Cancer Center, CB #7295University of North CarolinaChapel HillUSA

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