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Current Oncology Reports

, Volume 3, Issue 4, pp 314–321 | Cite as

Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention

  • Norman F. Boyd
  • Lisa J. Martin
  • Jennifer Stone
  • Cary Greenberg
  • Salomon Minkin
  • Martin J. Yaffe
Article

Abstract

Differences in the parenchymal pattern of the breast on mammography reflect differences in the amounts of stromal, epithelial, and fat tissue present in the breast. Stroma and epithelium are radiologically dense, whereas fat is lucent. Extensive areas of mammographically dense breast tissue are strongly associated with an increased risk of breast cancer. A variety of interventions, including gonadotropin-releasing hormone inhibitor, tamoxifen, stopping hormone replacement therapy (HRT), and adopting a low-fat, high-carbohydrate diet, all influence the tissue composition of the breast and reduce mammographic densities. Of the interventions examined to date, only tamoxifen has been shown to reduce the incidence of breast cancer, at least in the short term. Conversely, HRT, which increases density, also increases risk of breast cancer. These results suggest that mammographic density may be a short-term marker of the effect on the breast of potential preventive interventions for breast cancer.

Keywords

Breast Cancer Tamoxifen Breast Cancer Risk Raloxifene Mammographic Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • Norman F. Boyd
    • 1
  • Lisa J. Martin
    • 1
  • Jennifer Stone
    • 1
  • Cary Greenberg
    • 1
  • Salomon Minkin
    • 1
  • Martin J. Yaffe
    • 1
  1. 1.Division of Epidemiology and StatisticsOntario Cancer InstituteTorontoCanada

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