Current Oncology Reports

, Volume 3, Issue 3, pp 271–278 | Cite as

Upfront transplantation for poor-risk aggressive non-hodgkin lymphoma and hodgkin’s disease: Who benefits?

  • Tarun Kewalramani
  • Craig H. Moskowitz


High-dose therapy with autologous stem-cell transplantation is the standard treatment for patients with relapsed or primary refractory Hodgkin’s disease or non-Hodgkin lymphoma. The efficacy of the treatment in this setting has prompted extensive investigation of its role in upfront therapy for patients with a poor prognosis. Although the preliminary data appear promising, definitive results are still lacking, and upfront transplantation remains investigational. Newer regimens for the treatment of advanced-stage Hodgkin’s disease appear to confer cure rates of approximately 85% to 90%. Thus, only a small minority of patients may potentially benefit from more aggressive therapy such as upfront transplantation. A reliable method of identifying these patients is yet to be determined. Upfront transplantation should be evaluated in these patients once they are identified.


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Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • Tarun Kewalramani
    • 1
  • Craig H. Moskowitz
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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