Current Oncology Reports

, Volume 3, Issue 2, pp 179–184 | Cite as

Multiple daily fractionation radiotherapy schedules in lung cancer

  • Craig A. Schulz
  • Paul M. Harari
  • Minesh P. Mehta


Lung cancer is the number one worldwide cancer killer, and in spite of therapeutic advances, the overall impact on survival has remained very modest. For both small and non-small-cell lung cancer, treatment trends have shifted toward combined-modality approaches, chemotherapy for the control of systemic micrometastases, and radiotherapy for intrathoracic control. However, on both counts, rates of failure remain unacceptably high, and several novel strategies are currently being explored. The use of altered fractionation, including multiple daily fractions, reflects one approach for modifying radiotherapy. The two most common approaches are hyperfractionation and acceleration, the former designed to reduce late normal tissue toxicities and the latter to counteract accelerated tumor repopulation. Recent randomized trials suggest that such approaches may result not only in lowered rates of intrathoracic failure but also in improved survival.


Radiat Oncol Biol Phys Radiation Therapy Oncology Group Thoracic Radiotherapy Biological Equivalent Dose Altered Fractionation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc. 2001

Authors and Affiliations

  • Craig A. Schulz
    • 1
  • Paul M. Harari
    • 1
  • Minesh P. Mehta
    • 1
  1. 1.Department of Human OncologyUniversity of Wisconsin Medical SchoolMadisonUSA

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