Clinical Characteristics and Treatment of MOG-IgG–Associated Optic Neuritis

  • Deena A. Tajfirouz
  • M. Tariq Bhatti
  • John J. ChenEmail author
Neuro-Ophthalmology (R. Mallery, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Neuro-Ophthalmology


Purpose of Review

Antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with a unique acquired central nervous system demyelinating disease—termed MOG-IgG-associated disorder (MOGAD)—which has a variety of clinical manifestations, including optic neuritis, transverse myelitis, acute disseminating encephalomyelitis, and brainstem encephalitis. In this review, we summarize the current knowledge of the clinical characteristics, neuroimaging, treatments, and outcomes of MOGAD, with a focus on optic neuritis.

Recent Findings

The recent development of a reproducible, live cell–based assay for MOG-IgG, has improved our ability to identify and study this disease. Based on contemporary studies, it has become increasingly evident that MOGAD is distinct from multiple sclerosis and aquaporin-4-positive neuromyelitis optica spectrum disorder with different clinical features and treatment outcomes.


There is now sufficient evidence to separate MOGAD from other inflammatory central nervous system demyelinating disorders, which will allow focused research on understanding the pathophysiology of the disease. Prospective treatment trials are needed to determine the best course of treatment, and until then, treatment plans must be individualized to the clinical manifestations and severity of disease.


Optic neuritis Myelin oligodendrocyte glycoprotein (MOG) Aquaporin-4 (AQP4) Neuromyelitis optica spectrum disorder (NMOSD) Acute disseminating encephalomyelitis (ADEM) Multiple sclerosis 





immunoglobulin G


myelin oligodendrocyte glycoprotein


magnetic resonance imaging


neuromyelitis optica spectrum disorder


optic neuritis


Compliance with Ethical Standards

Conflict of Interest

Deena A. Tajfirouz, M. Tariq Bhatti, and John J. Chen each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Deena A. Tajfirouz
    • 1
  • M. Tariq Bhatti
    • 1
    • 2
  • John J. Chen
    • 1
    • 2
    Email author
  1. 1.Department of NeurologyMayo ClinicRochesterUSA
  2. 2.Department of OphthalmologyMayo ClinicRochesterUSA

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