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Sleep Disturbance and Cognitive Dysfunction in Multiple Sclerosis: a Systematic Review

  • Abbey J. HughesEmail author
  • Katherine M. Dunn
  • Trisha Chaffee
Sleep (M Thorpy and M Billiard, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Pediatric Neurology

Abstract

Purpose of Review

The present review summarizes recent research on the association between sleep disturbance and cognitive dysfunction in MS. Assessment methodology, domain-specific associations between sleep disturbance and cognitive dysfunction, and implications for future research and treatment are discussed.

Recent Findings

All 12 studies included in this review found significant associations between sleep disturbance and cognitive dysfunction; however, results varied considerably depending on the assessment method used and the cognitive domain assessed. Self-reported sleep disturbance generally predicted self-report but not objective measures of cognitive dysfunction. Objective sleep measures (e.g., polysomnography, actigraphy) generally predicted objective impairments in processing speed and attention; however, objective sleep disturbance was more variable in predicting performance in other cognitive domains (e.g., memory, executive function).

Summary

Sleep disturbance may help predict future cognitive decline in MS. Results highlight the need to integrate sleep assessment into routine MS care. Interventions aimed treating sleep disturbance may offer promise for improving cognitive dysfunction in MS.

Keywords

Multiple sclerosis Sleep Sleep disturbance Sleep disorders Cognitive dysfunction Cognitive impairment 

Notes

Compliance with Ethical Standards

Conflict of Interest

Katherine M. Dunn and Trisha Chaffee declare no conflict of interest.

Abbey J. Hughes reports grants from the National Institutes of Health.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Abbey J. Hughes
    • 1
    Email author
  • Katherine M. Dunn
    • 1
    • 2
  • Trisha Chaffee
    • 1
  1. 1.Department of Physical Medicine and Rehabilitation, Division for Rehabilitation Psychology and NeuropsychologyJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of PsychologyLoyola University MarylandBaltimoreUSA

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