Marijuana Use in Epilepsy: The Myth and the Reality

  • Kamil DetynieckiEmail author
  • Lawrence Hirsch
Epilepsy (CW Bazil, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Epilepsy


Marijuana has been utilized as a medicinal plant to treat a variety of conditions for nearly five millennia. Over the past few years, there has been an unprecedented interest in using cannabis extracts to treat epilepsy, spurred on by a few refractory pediatric cases featured in the media that had an almost miraculous response to cannabidiol-enriched marijuana extracts. This review attempts to answer the most important questions a clinician may have regarding the use of marijuana in epilepsy. First, we review the preclinical and human evidences for the anticonvulsant properties of the different cannabinoids, mainly tetrahydrocannabinol (THC) and cannabidiol (CBD). Then, we explore the safety data from animal and human studies. Lastly, we attempt to reconcile the controversy regarding physicians’ and patients’ opinions about whether the available evidence is sufficient to recommend the use of marijuana to treat epilepsy.


Marijuana Cannabinoids Epilepsy Cannabidiol Tetrahydrocannabinol 


Compliance with Ethics Guidelines

Conflict of Interest

Kamil Detyniecki has received research grants from Eisai, Lundbeck, and Sunovion and an honoraria payment from Eisai.

Lawrence Hirsch has received consultancy fees from Lundbeck, Upsher-Smith, and GlaxoSmithKline, grants from UCB-Pharma, Upsher-Smith, Lundbeck, Eisai, and Sunovion, and royalty payments from UpToDate, Inc. and Medlink Corporation.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance•• Of major importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Yale Comprehensive Epilepsy Center, Department of NeurologyYale UniversityNew HavenUSA

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