Reversal of Anticoagulant Effects in Patients with Intracerebral Hemorrhage

Stroke (HP Adams, Section Editor)
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  1. Topical Collection on Stroke


Anticoagulant therapies are increasingly being used for the treatment and prevention of thromboembolic diseases. A growing incidence of anticoagulant-associated intracranial hemorrhage (AICH) has accompanied the rise in their use. Although the rate of intracerebral hemorrhage (ICH) in patients receiving anticoagulation therapies such as heparin and target-specific oral anticoagulants (TSOAs) is significantly lower than that of vitamin K antagonists (VKAs), the mortality rate remains high. TSOAs have only recently become available for use in clinical practice, and presently, there is a paucity of both clinical data and evidence-based guidelines to assist in the management of TSOA-associated intracerebral hemorrhage. In this article, we review current literature and provide physicians with diagnostic and therapeutic considerations for the management of AICH.


Anticoagulants Apixaban Dabigatran Intracerebral hemorrhage Target-specific oral anticoagulants Prothrombin complex concentrate Rivaroxaban Vitamin K Warfarin 


Compliance with Ethics Guidelines

Conflict of Interest

Sean Yates declares no conflict of interest.

Ravi Sarode is a consultant for CSL Behring and Octapharma.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Transfusion Medicine and Hemostasis, Department of PathologyUT Southwestern Medical CenterDallasUSA

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