Gut Microbiome and Multiple Sclerosis
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The commensal flora that lives in the human gut is a unique ecosystem that has evolved over millennia with human beings. The importance of the microbiota in various bodily functions is gradually becoming more apparent. Besides the gut microbiome playing a role in bowel-related disorders, a role in metabolic and autoimmune disorders is becoming clearer. The gut bacteria play a role in educating the immune system and hence may be a player in the development of multiple sclerosis. We examine the different sources of information linking the gut microbiota to multiple sclerosis and examine the future avenues for utilizing the knowledge of the gut microbiome to potentially treat and prevent multiple sclerosis.
KeywordsMicrobiome Multiple sclerosis
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Conflict of Interest
Pavan Bhargava declares he has no conflict of interest.
Ellen M. Mowry has received grants from Teva Neuroscience.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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- 4.Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1994;179:973–84.PubMedCrossRefGoogle Scholar
- 5.Quigley EMM. Gut bacteria in health and disease. Gastroenterol Hepatol (N Y). 2013;9:560–9.Google Scholar
- 11.•Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al. Enterotypes of the human gut microbiome. Nature. 2011;473:174–80. Arumugam et al. introduced the concept of gut enterotypes and attempte to correlate these with other host characteristics.PubMedCrossRefPubMedCentralGoogle Scholar
- 15.••Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2011;108(Suppl):4615–22. Lee et al. demonstrated that germ-free mice that were resistant to EAE were rendered susceptible by the introduction of segmented filamentous bacteria into their gut microbiome. This phenomenon was mediated through an increased generation of proinflammatory Th17 cells.PubMedCrossRefPubMedCentralGoogle Scholar
- 27.Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, Eeckhaut V, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2013;1–9.Google Scholar
- 48.••Berer K, Mues M, Koutrolos M, Al Rasbi Z, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479:538–41. Berer et al. used a mouse that develops spontaneous EAE to demonstrate that the gut microbiota induces production of CNS autoreactive proinflammatory T cells, which then recruit autoreactive B cells and increase production of antibodies against myelin antigen.PubMedCrossRefGoogle Scholar
- 51.•Rumah KR, Linden J, Fischetti VA, Vartanian T. Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One. 2013;8:e76359. Rumah et al. described the identification of a strain of Clostridium perfringens that produces epsilon toxin which could potentially lead to oligodendrocyte damage and be a trigger for an autoimmune reaction against myelin.PubMedCrossRefPubMedCentralGoogle Scholar
- 56.Jhangi S, Gandhi R, Glanz B, Cook S, Nejad P, Ward D, et al. Increased Archaea species and changes with therapy in gut microbiome of multiple sclerosis subjects (S24. 001). Neurology. 2014;82(10 Suppl):S24.001.Google Scholar
- 58.Mowry EM, Waubant E, Chehoud C, DeSantis T, Kuczynski J, Warrington J. Gut bacterial populations in multiple sclerosis and in health (P05.106). Neurology. 2012;78(Meet Abstr 1):P05.106.Google Scholar