Arterial Ischemic Stroke in Children: Risk Factors and Etiologies

Stroke (H Adams, Section Editor)

DOI: 10.1007/s11910-013-0422-8

Cite this article as:
Numis, A.L. & Fox, C.K. Curr Neurol Neurosci Rep (2014) 14: 422. doi:10.1007/s11910-013-0422-8
Part of the following topical collections:
  1. Topical Collection on Stroke


Stroke is increasingly recognized as a significant cause of morbidity and mortality in children, and as a financial burden for families and society. Recent studies have identified and confirmed presumptive risk factors, and have identified novel associations with childhood arterial ischemic stroke. A better understanding of risk factors for stroke in children, which differ from the atherosclerotic risk factors in adults, is the first step needed to improve strategies for stroke prevention and intervention, and ultimately minimize the physical, mental, and financial burden of arterial ischemic stroke. Here, we discuss recent advances in research for selected childhood stroke risk factors, highlighting the progress made in our understanding of etiologic mechanisms and pathophysiology, and address the future directions for acute and long-term treatment strategies for pediatric stroke.


Pediatric stroke Cerebral arteriopathy Cranial radiation Sickle cell disease Congenital heart disease Patent foramen ovale 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Child NeurologyUniversity of California, San FranciscoSan FranciscoUSA

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