Depression and Parkinson’s Disease: Current Knowledge

  • Laura Marsh
Movement Disorders (SA Factor, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Movement Disorders


Depressive disturbances are common in patients with Parkinson’s disease (PD) and influence many other clinical aspects of the disease. In addition to causing inherent emotional distress, depressive disorders negatively impact quality of life, motor and cognitive deficits, functional disability, and other psychiatric comorbidities in patients with PD. Knowledge of the pathophysiology of PD depression remains limited. However, clinical studies demonstrate the efficacy of medications and psychotherapies for PD depression, underscoring the importance of their timely detection and concerted management.


Depression Parkinson’s disease Mood disorder Psychiatric Antidepressant Cognitive behavioral therapy Electroconvulsive therapy Quality of life Treatment Suicide Major depression: dysthymia Minor depression Subsyndromal depression Epidemiology Pathophysiology 


Compliance with Ethics Guidelines

Conflict of Interest

Laura Marsh has been a consultant for Roche Pharmaceuticals for the development of clinical trial designs to test interventions for apathy in Parkinson's disease. She is employed by the Michael E. DeBakey Veterans Affairs Medical Center. She is a site investigator for the Dystonia Coalition U54 NS065701.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the author.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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© Springer Science+Business Media New York (outside the USA) 2013

Authors and Affiliations

  1. 1.Baylor College of Medicine, Departments of Psychiatry and NeurologyMichael E. DeBakey Veterans Affairs Medical CenterHoustonUSA

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