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Spinocerebellar Ataxia Type 10: From Amerindians to Latin Americans

  • Hélio A. G. Teive
  • Tetsuo Ashizawa
Invited Commentary

Introduction

Autosomal dominant cerebellar ataxias, currently denominated spinocerebellar ataxias (SCAs), constitute a large, complex group of heterogeneous autosomal dominant degenerative diseases characterized by progressive degeneration of the cerebellum and its afferent and efferent connections [1, 2]. Other nervous system structures are usually affected, including the basal ganglia, brainstem nuclei, pyramidal tracts, and posterior column and anterior horn of the spinal cord, as well as the peripheral nerves. SCAs are clinically characterized by the presence of cerebellar gait, limb ataxia (with dysmetria,dysdiadochokinesia, intention tremor), scanning dysarthria, dysphagia, nystagmus, and ocular motility abnormalities, which may be accompanied by extracerebellar signs such as ophthalmoplegia, pyramidal signs, movement disorders (including parkinsonism, dystonia, myoclonus, and chorea), dementia, epilepsy, visual disorders (including pigmentary retinopathy), lower motor neuron...

Keywords

Spinocerebellar ataxia type 10 Epidemiology History Amerindians Latin Americans 

Notes

Acknowledgment

Tetsuo Ashizawa has received grant support through the University of Florida as his salary support (NIH grant NS083564).

Compliance with Ethics Guidelines

Conflict of Interest

Hélio A.G. Teive declares that he has no conflict of interest.

Tetsuo Ashizawa has received support for travel to meetings for the study or otherwise from the University of Rochester (to attend an investigator meeting for a study funded by the Muscular Dystrophy Association) and the Muscular Dystrophy Association (to attend the Medical Advisory Committee). He also receives royalties from Baylor College of Medicine for an invention relating to genetic testing.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Movement Disorders Unit, Neurology Service, Hospital de ClínicasFederal University of ParanáCuritibaBrazil
  2. 2.Department of NeurologyUniversity of FloridaGainesvilleUSA

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