Current Neurology and Neuroscience Reports

, Volume 12, Issue 6, pp 715–723 | Cite as

Recent Advances in the Imaging of Frontotemporal Dementia

  • Jennifer L. Whitwell
  • Keith A. JosephsEmail author
Behavior (HS Kirshner, Section Editor)


Neuroimaging has played an important role in the characterization of the frontotemporal dementia (FTD) syndromes, demonstrating neurodegenerative signatures that can aid in the differentiation of FTD from other neurodegenerative disorders. Recent advances have been driven largely by the refinement of the clinical syndromes that underlie FTD, and by the discovery of new genetic and pathological features associated with FTD. Many new imaging techniques and modalities are also now available that allow the assessment of other aspects of brain structure and function, such as diffusion tensor imaging and resting-state functional MRI. Studies have used these recent techniques, as well as traditional volumetric MRI, to provide further insight into disease progression across the many clinical, genetic, and pathological variants of FTD. Importantly, neuroimaging signatures have been identified that will improve the clinician’s ability to predict underlying genetic and pathological features, and hence ultimately improve patient diagnosis.


Magnetic resonance imaging Diffusion tensor imaging Resting-state functional magnetic resonance imaging Behavioral variant frontotemporal dementia Semantic dementia Agrammatic Apraxia of speech C9orf72 hexanucleotide repeat Progranulin Tau Transactivation response element DNA binding protein of 43 kDa Fused in sarcoma Atrophy White matter tracts Functional connectivity 



J.L. Whitwell: consultant (Bristol-Myers Squibb); K.A. Josephs: none.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of RadiologyMayo ClinicRochesterUSA
  2. 2.Department of NeurologyMayo ClinicRochesterUSA

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