Current Neurology and Neuroscience Reports

, Volume 11, Issue 2, pp 124–126

Risk Stratification of Medulloblastoma: A Paradigm for Future Childhood Brain Tumor Management Strategies

Clinical Trial Report

References

  1. 1.
    Packer RJ, Gajjar A, Vezina G, et al.: Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 22006;24(25):4202.Google Scholar
  2. 2.
    Kortmann RD, Kuhl J, Timmermann B, et al.: Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT’91. Int J Radiat Oncol Biol Phys 2000;46(2):269.PubMedCrossRefGoogle Scholar
  3. 3.
    Packer RJ, Gurney JG, Punyko JA, et al.: Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study. J Clin Oncol 2003; 21(17):3255.PubMedCrossRefGoogle Scholar
  4. 4.
    Packer RJ, Cogen P, Vezina G, et al.: Medulloblastoma: clinical and biologic aspects. Neuro Oncol 1999; 1(3):232.PubMedGoogle Scholar
  5. 5.
    Rutkowski S, Bode U, Deinlein F, et al.: Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 352(10): 978, 2005.PubMedCrossRefGoogle Scholar
  6. 6.
    Gajjar A, Hernan R, Kocak M, et al.: Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma. J Clin Oncol 22:984–993, 2004.PubMedCrossRefGoogle Scholar
  7. 7.
    Pfister S, Remke M, Benner A, et al.: Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J Clin Oncol 27:1627–1638, 2009.PubMedCrossRefGoogle Scholar
  8. 8.
    Kool M, Koster J, Bunt J, et al.: Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 2008;3(8):e3088.PubMedCrossRefGoogle Scholar
  9. 9.
    Pomeroy SL, Tamayo P, Gaasenbeek M, et al.: Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415:436–442, 2002.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Center for Neuroscience and Behavioral MedicineGilbert Neurofibromatosis Institute, Brain Tumor Institute, Children’s National Medical CenterWashingtonUSA

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