Current Neurology and Neuroscience Reports

, Volume 11, Issue 1, pp 104–110

Neurocritical Care of a Reperfused Brain

  • Aamir Badruddin
  • Muhammad A. Taqi
  • Michael G. Abraham
  • Dhimant Dani
  • Osama O. Zaidat


Cerebral hyperperfusion and reperfusion injuries are not infrequently encountered following in reperfusion of ischemic or hypoperfused brain. Mechanism of injury could be related to tissue plasminogen activator toxicity, oxidative stress, and hyperperfusion due to impaired cerebral autoregulation in already maximally dilated cerebral vasculature and compromised cerebral hemodynamic reserve. Reperfusion injury can present as headaches and seizures in mild forms and as subarachnoid hemorrhage, intracranial hemorrhage, cerebral edema, and encephalopathy in its most severe manifestation. Prevention and identifying those at risk of hyperperfusion syndromes are the best strategy. Active treatment includes basic neurocritical care with reduction of blood pressure to a reperfused brain and timely neuroprotection and cerebral edema control measures are the mainstay of its management approach.


Neurointervention Neurocritical care Hyperperfusion Intracranial stenting Carotid stenting Stroke thrombolysis Thrombolysis Stenting Angioplasty Critical care Stroke Reperfusion 


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Aamir Badruddin
    • 2
  • Muhammad A. Taqi
    • 2
  • Michael G. Abraham
    • 2
  • Dhimant Dani
    • 2
  • Osama O. Zaidat
    • 1
  1. 1.Department of Neurology, Radiology and NeurosurgeryMedical College of Wisconsin and Froedtert Hospital WestMilwaukeeUSA
  2. 2.Department of NeurologyMedical College of Wisconsin and Froedtert Hospital WestMilwaukeeUSA

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