Current Neurology and Neuroscience Reports

, Volume 10, Issue 6, pp 484–490 | Cite as

The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants



Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer’s disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.


Primary progressive aphasia (PPA) Semantic variant PPA (svPPA) Semantic dementia (SD) Semantic PPA (PPA-S) Logopenic variant PPA (lvPPA) Logopenic progressive aphasia (LPA) Logopenic PPA (PPA-L) Nonfluent/agrammatic variant PPA (navPPA) Progressive nonfluent aphasia (PNFA) Agrammatic PPA (PPA-G) Frontotemporal dementia (FTD, FTLD) Alzheimer’s disease (AD) 



Michael F. Bonner has received grant support from the US National Institutes of Health (NIH). Sharon Ash has received grants from NIH (AG15116, AG17586, NS44266, and NS53488). Murray Grossman has received grants from NIH (NS054575, AG15116, AG17586, NS44266, NS53488, and AG32953).


Murray Grossman is a member and a medical advisor for the board of the Association for Frontotemporal Dementias; he has been a consultant for Pfizer, Forest, and Allon; he has received honoraria for Ground Rounds, Penn State; and has received expenses for travel/accommodations for Grand Rounds, UCSF, and McGill. Sharon Ash has received royalties from Mouton de Gruyter for The Atlas of North American English: Phonetics, Phonology and Sound Change, published in 2006.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michael F. Bonner
    • 1
  • Sharon Ash
    • 1
    • 2
  • Murray Grossman
    • 1
  1. 1.Department of Neurology, 2 GibsonHospital of the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Neurology, 3 West GatesHospital of the University of PennsylvaniaPhiladelphiaUSA

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