Current Neurology and Neuroscience Reports

, Volume 10, Issue 3, pp 155–157 | Cite as

The Role of Temozolomide in Elderly Patients with Glioblastoma

Clinical Trial Report
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Notes

Disclosure

No potential conflict of interest relevant to this article was reported.

References

  1. 1.
    Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987–996.CrossRefPubMedGoogle Scholar
  2. 2.
    Keime-Guibert F, Chinot O, Taillandier L, et al.: Radiotherapy for glioblastoma in the elderly. N Engl J Med 2007, 356:1527–1535.CrossRefPubMedGoogle Scholar
  3. 3.
    Hegi ME, Diserens AC, Gorlia T, et al.: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005, 352:997–1003.CrossRefPubMedGoogle Scholar
  4. 4.
    Brandes AA, Vastola F, Basso U, et al.: A prospective study on glioblastoma in the elderly. Cancer 2003, 97:657–662.CrossRefPubMedGoogle Scholar
  5. 5.
    Combs SE, Wagner J, Bischof M, et al.: Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients. Int J Radiat Oncol Biol Phys 2008, 70:987–992.PubMedGoogle Scholar
  6. 6.
    Minniti G, De Sanctis V, Muni R, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol 2008, 88:97–103.CrossRefPubMedGoogle Scholar
  7. 7.
    Sijben AE, McIntyre JB, Roldan GB, et al.: Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J Neurooncol 2008, 89:97–103.CrossRefPubMedGoogle Scholar
  8. 8.
    Batchelor TT, Betensky RA, Esposito JM, et al.: Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res 2004, 10:228–233.CrossRefPubMedGoogle Scholar
  9. 9.
    Jaeckle KA, Eyre HJ, Townsend JJ, et al.: Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study. J Clin Oncol 1998, 16:3310–3315.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Memorial Sloan Kettering Cancer CenterNew YorkUSA

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