Current Neurology and Neuroscience Reports

, Volume 10, Issue 3, pp 215–223

The Genetics of Pediatric Brain Tumors

  • Adrian M. Dubuc
  • Paul A. Northcott
  • Stephen Mack
  • Hendrik Witt
  • Stefan Pfister
  • Michael D. Taylor
Article

Abstract

Brain tumors are the most common childhood solid malignancy and the leading cause of cancer-related death in children. Medulloblastoma, ependymoma, supratentorial primitive neuroectodermal tumors, and pilocytic astrocytoma are the most prevalent types, all of which are clinically, histologically, and genetically heterogeneous. Despite an incomplete molecular understanding of these tumors, we have made significant headway in the past 5 years in identifying and classifying important genetic alterations and pathways central to the disease process. This review summarizes our current state of knowledge, emphasizes recent seminal findings in the field, and proposes future research efforts needed to further characterize the genetic basis of pediatric brain tumors.

Keywords

Medulloblastoma Ependymoma Supratentorial primitive neuroectodermal tumor Pilocytic astrocytoma Genetics Epigenetics Cytogenetics Pediatric brain tumors 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Adrian M. Dubuc
    • 1
    • 2
    • 3
  • Paul A. Northcott
    • 1
    • 2
    • 3
  • Stephen Mack
    • 1
    • 2
    • 3
  • Hendrik Witt
    • 4
    • 5
  • Stefan Pfister
    • 4
    • 5
  • Michael D. Taylor
    • 1
    • 2
    • 3
    • 6
  1. 1.Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research CentreThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Program in Developmental and Stem Cell BiologyThe Hospital for Sick ChildrenTorontoCanada
  3. 3.Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoCanada
  4. 4.German Cancer Research Center, Molecular Genetics of Pediatric Brain TumorsHeidelbergGermany
  5. 5.Department of Pediatric Oncology, Hematology and ImmunologyUniversity of HeidelbergHeidelbergGermany
  6. 6.Division of Neurosurgery, Department of SurgeryHospital for Sick ChildrenTorontoCanada

Personalised recommendations