Current Neurology and Neuroscience Reports

, Volume 10, Issue 2, pp 73–82 | Cite as

Management of Intraventricular Hemorrhage

  • Holly E. Hinson
  • Daniel F. HanleyEmail author
  • Wendy C. Ziai


Brain hemorrhage is the most fatal form of stroke and has the highest morbidity of any stroke subtype. Intraventricular extension of hemorrhage (IVH) is a particularly poor prognostic sign, with expected mortality between 50% and 80%. IVH is a significant and independent contributor to morbidity and mortality, yet therapy directed at ameliorating intraventricular clot has been limited. Conventional therapy centers on managing hypertension and intracranial pressure while correcting coagulopathy and avoiding complications such as rebleeding and hydrocephalus. Surgical therapy alone has not changed the natural history of the disease significantly. However, fibrinolysis in combination with extraventricular drainage shows promise as a technique to reduce intraventricular clot volume and to manage the concomitant complications of IVH.


Intraventricular Hemorrhage Intracerebral hemorrhage External ventricular drainage 



Dr. Hanley and Dr. Ziai are investigators in the CLEAR-IVH trial, which is sponsored by the US Food and Drug Administration’s orphan drug program and assisted by a donation from Cathflo and a sponsored research agreement from Genentech (use patent: Johns Hopkins medical institutions). No other potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Holly E. Hinson
    • 1
  • Daniel F. Hanley
    • 1
    Email author
  • Wendy C. Ziai
    • 1
  1. 1.Neurosciences Critical Care DivisionThe Johns Hopkins University School of MedicineBaltimoreUSA

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