Current Neurology and Neuroscience Reports

, Volume 9, Issue 6, pp 430–434 | Cite as

Neurologic manifestations of varicella zoster virus infections

  • Catherine Amlie-Lefond
  • Burk Jubelt


Varicella zoster virus (VZV) causes acute viral exanthema in childhood, becomes latent, and can reactivate years later to produce neurologic disease. Primary VZV infection is associated with acute cerebellitis and stroke, particularly in childhood. VZV reactivation may result in neuropathy, myelitis, stroke, and encephalitis, the latter two syndromes the result of small and large vessel vasculopathy. Prompt diagnosis and treatment are critical to minimize morbidity in herpes zoster as well as morbidity and death in VZV vasculitis and encephalitis. Detection of anti-VZV antibodies in cerebrospinal fluid is the most sensitive method of diagnosing varicella infection of the nervous system. Despite the advent of the VZV vaccine, varicella remains a significant cause of neurologic morbidity.


Dorsal Root Ganglion Herpes Zoster Varicella Zoster Virus Postherpetic Neuralgia Chickenpox 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group, LLC 2009

Authors and Affiliations

  1. 1.Department of NeurologyMedical College of Wisconsin and Children’s Hospital of WisconsinMilwaukeeUSA

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