Current Neurology and Neuroscience Reports

, Volume 9, Issue 4, pp 327–332 | Cite as

An update on brain stimulation for epilepsy

  • Christopher Todd Anderson
  • Kathryn Davis
  • Gordon Baltuch
Article

Abstract

Brain stimulation for epilepsy has been explored for decades. Nevertheless, this area has traditionally been associated with small poorly controlled trials, inconsistent results, and a resultant lack of widespread use of these technologies. Due to the success of deep brain stimulation for movement disorders and unprecedented advances in computer technology and bioengineering, brain stimulation recently has again generated great interest in epilepsy care. Several large-scale, randomized, blinded, multicenter trials have been conducted; the most up-to-date findings are summarized in this article. These treatment modalities will likely improve over time. The hope that they provide to patients with refractory epilepsy cannot be underestimated.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References and Recommended Reading

  1. 1.
    Litt B: Evaluating devices for epilepsy. Epilepsia 2003, 44(Suppl 7):30–37.PubMedCrossRefGoogle Scholar
  2. 2.
    Upton AR, Cooper IS, Springman M, et al.: Suppression of seizures and psychosis of limbic system origin by chronic stimulation of anterior nucleus of the thalamus. Int J Neurol 1985, 19–20:223–230.PubMedGoogle Scholar
  3. 3.
    Rosenow J, Das K, Rovit RL, et al.: Irving S. Cooper and his role in intracranial stimulation for movement disorders and epilepsy. Stereotact Funct Neurosurg 2002, 78:95–112.PubMedCrossRefGoogle Scholar
  4. 4.
    Upton AR, Amin I, Garnett S, et al.: Evoked metabolic responses in the limbic-striate system produced by stimulation of the anterior thalamic nucleus in man. Pacing Clin Electrophysiol 1987, 10(1 Pt 2):217–225.PubMedCrossRefGoogle Scholar
  5. 5.
    Hodaie M, Wennberg RA, Dostrovsky JO, et al.: Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia 2002, 43:603–608.PubMedCrossRefGoogle Scholar
  6. 6.
    Kerrigan JF, Litt B, Fisher RS, et al.: Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy. Epilepsia 2004, 45:346–354.PubMedCrossRefGoogle Scholar
  7. 7.
    Velasco F, Velasco M, Ogarrio C, et al.: Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia 1987, 28:167–179.CrossRefGoogle Scholar
  8. 8.
    Fisher RS, Uematsu S, Krauss GL, et al.: Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia 1992, 33:841–851.PubMedCrossRefGoogle Scholar
  9. 9.
    Velasco M, Velasco F, Velasco AL: Centromedian-thalamic and hippocampal electrical stimulation for the control of intractable epileptic seizures. J Clin Neurophysiol 2001, 18:495–513.PubMedCrossRefGoogle Scholar
  10. 10.
    Andrade DM, Zumsteg D, Hamani C, et al.: Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy. Neurology 2006, 66:1571–1573.PubMedCrossRefGoogle Scholar
  11. 11.
    Sussman NM, Goldman HW, Jackel RA, et al.: Anterior thalamus stimulation in medically intractable epilepsy, part II. Preliminary clinical trials [abstract]. Epilepsia 1988, 29:667.Google Scholar
  12. 12.
    Lim SN, Lee ST, Tsai YT, et al.: Electrical stimulation of the anterior nucleus of the thalamus for intractable epilepsy: a long-term follow-up study. Epilepsia 2007, 48:342–347.PubMedCrossRefGoogle Scholar
  13. 13.
    Osorio I, Overman J, Giftakis J, et al.: High frequency thalamic stimulation for inoperable mesial temporal epilepsy. Epilepsia 2007, 48:1561–1571.PubMedCrossRefGoogle Scholar
  14. 14.
    Pilitsis JG, Chu Y, Kordower J, et al.: Postmortem study of deep brain stimulation of the anterior thalamus: case report. Neurosurgery 2008, 62:E530–E532.PubMedCrossRefGoogle Scholar
  15. 15.
    Fisher R: SANTE® (Stimulation the Thalamus for Epilepsy). William G. Lennox Lecture. Presented at the 62nd annual meeting of the American Epilepsy Society. Seattle; December 8, 2008.Google Scholar
  16. 16.
    Morrell M: Brain stimulation for epilepsy: Can scheduled or responsive neurostimulation stop seizures? Curr Opin Neurol 2006, 19:164–168.PubMedCrossRefGoogle Scholar
  17. 17.
    Sun FT, Morrell MJ, Wharen RE: Responsive cortical stimulation for the treatment of epilepsy. Neurotherapeutics 2008, 5:68–74.PubMedCrossRefGoogle Scholar
  18. 18.
    Morrell, MJ, Hirsch LJ, Bergey G, et al.: Long-term safety and efficacy of the RNSTM system in adults with medically intractable partial onset seizures [abstract]. Epilepsia 2008, 49(Suppl 7):480.Google Scholar
  19. 19.
    Tellez-Zenteno JF, McLachlan RS, Parrent A, et al.: Hippocampal electrical stimulation in mesial temporal lobe epilepsy. Neurology 2006, 66:562–565.CrossRefGoogle Scholar
  20. 20.
    Boon P, Vonck K, De Herdt V, et al.: Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia 2007, 48:1551–1560.PubMedCrossRefGoogle Scholar
  21. 21.
    Velasco AL, Velasco F, Velasco M, et al.: Electrical stimulation of the hippocampal epileptic foci for seizure control: a double-blind, long-term follow-up study. Epilepsia 2007, 48:1895–1903.PubMedCrossRefGoogle Scholar

Copyright information

© Current Medicine Group, LLC 2009

Authors and Affiliations

  • Christopher Todd Anderson
    • 1
  • Kathryn Davis
  • Gordon Baltuch
  1. 1.Department of Neurology, Penn Epilepsy CenterHospital of the University of PennsylvaniaPhiladelphiaUSA

Personalised recommendations