Recent advances in the genetics of dementia with Lewy bodies
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- Bonifati, V. Curr Neurol Neurosci Rep (2008) 8: 187. doi:10.1007/s11910-008-0030-1
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In the past few years, mutations have been identified in the genes encoding α-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson’s disease and DLB, as well as the presence of profound etiologic heterogeneity in Lewy body disorders.