Current Neurology and Neuroscience Reports

, Volume 7, Issue 6, pp 522–528 | Cite as

Thrombolytics in intraventricular hemorrhage

  • Paul NyquistEmail author
  • Shannon LeDroux
  • Romergryko Geocadin


Intraventricular hemorrhage (IVH) may occur as an isolated event from primary ventricular bleeding or as a complication of brain hemorrhage from another etiology. It is associated with high mortality and morbidity. Recent translational and clinical studies demonstrate that thrombolytic drugs administered intraventricularly through an external ventricular drain to lyse an IVH clot are safe and may reduce morbidity and mortality. The ongoing, prospective, randomized clinical trial known as Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage (CLEAR IVH) offers new hope for patients with this devastating disease. Preliminary data show marked reduction in time to clot lysis as well as a potential reduction in mortality associated with IVH lysis. A large, phase III, randomized prospective trial to ascertain the true clinical efficacy of this treatment is currently in the planning stages. A review of the use of thrombolytics for treatment of IVH related to other secondary causes is also provided.


Hydrocephalus Intracerebral Hemorrhage Intraventricular Hemorrhage Clot Lysis Spontaneous Intracerebral Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  • Paul Nyquist
    • 1
    Email author
  • Shannon LeDroux
  • Romergryko Geocadin
  1. 1.Division of Neurosciences Critical Care, Johns HopkinsUniversity School of MedicineBaltimoreUSA

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