Current Neurology and Neuroscience Reports

, Volume 7, Issue 3, pp 231–238

B cells: No longer the nondominant arm of multiple sclerosis

Article

DOI: 10.1007/s11910-007-0035-1

Cite this article as:
Klawiter, E.C. & Cross, A.H. Curr Neurol Neurosci Rep (2007) 7: 231. doi:10.1007/s11910-007-0035-1

Abstract

The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving. Recent discoveries include advances in lesion classification, identification of B cell clonal expansion in the central nervous system with evidence of antigen targeting, identification of chemokines in MS lesions, and expansion of information on the roles of autoantibodies and complement. Strong indications are accumulating that a greater degree of humoral dysfunction may lead to worsened long-term prognosis in MS. Effects of established MS treatments on B cells and their products have been further defined. Treatments that specifically target B cells are being implemented and hold promise.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Department of NeurologyWashington University School of MedicineSaint LouisUSA

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