Current Neurology and Neuroscience Reports

, Volume 7, Issue 1, pp 28–34 | Cite as

Treatment of arteriovenous malformations of the brain

  • Andreas HartmannEmail author
  • Henning Mast
  • Jae H. Choi
  • Christian Stapf
  • Jay P. Mohr


The treatment of ruptured and unruptured brain arteriovenous malformations (AVMs) is driven by the need to prevent incident or recurrent intracranial hemorrhages. Improving feasibility of the rapidly developing endovascular, neurosurgical, and radiotherapeutic procedures leads to invasive treatment of an increasing number of neurologically intact patients with accidentally diagnosed AVMs. Recent data confirm that the natural history risk of unruptured AVMs is significantly lower than the risk of those presenting with rupture, and the treatment risk of invasive management of unruptured AVMs seems higher than their natural history risk. The treatment decision algorithm for these patients remains unsettled, as no randomized clinical trial data exist on the benefit of invasive AVM treatment for patients with bled or with unbled AVMs. The recently launched study A Randomized Trial of Unruptured Brain AVMs (ARUBA) will be the first trial randomizing patients with nonhemorrhaged AVMs to invasive versus conservative management.


Arteriovenous Malformation Onyx Cerebral Arteriovenous Malformation Brain AVMs Brain Arteriovenous Malformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  • Andreas Hartmann
    • 1
    Email author
  • Henning Mast
  • Jae H. Choi
  • Christian Stapf
  • Jay P. Mohr
  1. 1.Stroke Unit, Department of Neurology, Charité — Hochschulmedizin BerlinCampus Benjamin FranklinBerlinGermany

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