Spinal neurons exhibit a surprising capacity to learn and a hidden vulnerability when freed from the brain’s control

  • James W. GrauEmail author
  • Michelle A. Hook
Invited Commentary


Spinal Cord Spinal Cord Injury Central Sensitization Spinal Neuron Instrumental Learning 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Patterson MM, Grau JW, eds: Spinal Cord Plasticity: Alterations in Reflex Function. Boston: Kluwer Academic Publishers; 2001.Google Scholar
  2. 2.
    Grau JW, Joynes RL: Pavlovian and instrumental conditioning within the spinal cord: methodological issues. In Spinal Cord Plasticity: Alterations in Reflex Function. Edited by Patterson MM, Grau J. Boston: Kluwer Academic Publishers; 2001:13–54.Google Scholar
  3. 3.
    Rescorla RA: Behavioral studies of Pavlovian conditioning. Ann Rev Neurosci 1988, 11:329–352.PubMedCrossRefGoogle Scholar
  4. 4.
    Patterson MM: Classical conditioning of spinal reflexes: the first seventy years. In Model Systems and the Neurobiology of Associative Learning. Edited by Steinmetz JE, Gluck MA, Solomon PR. Mahwah, NJ: Erlbaum; 2001:1–22.Google Scholar
  5. 5.
    Creasey GH, Ho CH, Triolo RJ, et al.: Clinical applications of electrical stimulation after spinal cord injury. J Spinal Cord Med 2004, 27:365–375.PubMedGoogle Scholar
  6. 6.
    Grau JW, Barstow DG, Joynes RL: Instrumental learning within the spinal cord: I. Behavioral properties. Behav Neurosci 1998, 112:1366–1386.PubMedCrossRefGoogle Scholar
  7. 7.
    Crown ED, Ferguson AR, Joynes RL, et al.: Instrumental learning within the spinal cord: II. Evidence for central mediation. Physiol Behav 2002, 77:259–267.PubMedCrossRefGoogle Scholar
  8. 8.
    Liu GT, Crown ED, Miranda RC, et al.: Instrumental learning within the rat spinal cord: localization of the essential neural circuit. Behav Neurosci 2005, 119:538–547.PubMedCrossRefGoogle Scholar
  9. 9.
    Maier SF, Seligman ME: Learned helplessness: theory and evidence. J Exp Psychol Gen 1976, 105:3–46.CrossRefGoogle Scholar
  10. 10.
    Crown ED, Joynes RL, Ferguson AR, et al.: Instrumental learning within the spinal cord: IV. Induction and retention of the behavioral deficit observed after noncontingent shock. Behav Neurosci 2002, 116:1032–1051.PubMedCrossRefGoogle Scholar
  11. 11.
    Joynes RL, Grau JW: Instrumental learning with the spinal cord: III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist. Neurobiol Learn Mem 2004, 82:35–51.PubMedCrossRefGoogle Scholar
  12. 12.
    Patton BC, Hook MA, Crown ED, et al.: The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide. Behav Neurosci 2004, 118:653–658.PubMedCrossRefGoogle Scholar
  13. 13.
    Coderre TJ: Noxious stimulus-induced plasticity in spinal cord dorsal horn: evidence and insights on mechanisms obtained using the formalin test. In Spinal Cord Plasticity: Alterations in Reflex Function. Edited by Patterson MM, Grau J. Boston: Kluwer Academic Publishers; 2001:163–183.Google Scholar
  14. 14.
    Willis WD: Mechanisms of central sensitization of nociceptive dorsal horn neurons. In Spinal Cord Plasticity: Alterations in Reflex Function. Edited by Patterson MM, J Grau. Boston: Kluwer Academic Publishers; 2001:127–161.Google Scholar
  15. 15.
    Ji RR, Kohno T, Moore KA, et al.: Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci 2003, 26:696–705.PubMedCrossRefGoogle Scholar
  16. 16.
    Ferguson AR, Crown ED, Grau JW: Nociceptive plasticity inhibits adaptive learning in the spinal cord. Neuroscience 2006, In press.Google Scholar
  17. 17.
    Moser EI, Moser MB: Is learning blocked by saturation of synaptic weights in the hippocampus? Neurosci Biobehav Rev 1999, 23:661–672.PubMedCrossRefGoogle Scholar
  18. 18.
    Yezierski RP: Pathophysiology and animal models of spinal cord injury pain. In Spinal Cord Injury Pain: Assessment, Mechanisms, Management. Edited by Yezierski RP, Burchiel KJ. Seattle, WA: IASP Press; 2002:117–136.Google Scholar
  19. 19.
    Gjerstad J, Tjolsen A, Hole K, et al.: Induction of long-term potentiation of single wide dynamic range neurones in the dorsal horn is inhibited by descending pathways. Pain 2001, 91:263–268.PubMedCrossRefGoogle Scholar
  20. 20.
    Crown ED, Grau JW: Evidence that descending systems protect behavioral plasticity against the disruptive effect of nociceptive stimulation. Exp Neurol 2005, 196:164–176.PubMedCrossRefGoogle Scholar
  21. 21.
    Washburn SN, Patton BC, Ferguson AR, et al.: Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function. Anesthesiology 2006, In press.Google Scholar
  22. 22.
    Grau JW, Washburn SN, Hook MA, et al.: Uncontrollable stimulation undermines recovery after spinal cord injury. J Neurotrauma 2004, 21:1795–1817.PubMedCrossRefGoogle Scholar
  23. 23.
    Bopp AC, Ferguson AR, Liu G, Grau JW: Brain dependent processes contribute to the adverse consequences of uncontrollable stimulation on the recovery of function. J Neurotrauma 2004, 21:1290.Google Scholar
  24. 24.
    Inamasu J, Nakamura Y, Ichikizaki K: Induced hypothermia in experimental traumatic spinal cord injury: an update. J Neurol Sci 2003, 209:55–60.PubMedCrossRefGoogle Scholar
  25. 25.
    Liu GT, Ferugson AR, Huie R: Morphine treatment slows recovery after a contusion injury in rats and does not reduce the negative consequences of aversive stimulation. Abstract Viewer/ Itinerary Planner CD-ROM. Washington, DC: Society for Neuroscience; 2004.Google Scholar
  26. 26.
    Edgerton VR, Leon RD, Harkema SJ: Retraining the injured spinal cord. J Physiol 2001, 533:15–22.PubMedCrossRefGoogle Scholar
  27. 27.
    Sandkuhler J, Liu X: Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. Eur J Neurosci 1998, 10:2476–2480.PubMedCrossRefGoogle Scholar

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© Current Science Inc 2006

Authors and Affiliations

  1. 1.Department of PsychologyTexas A&M UniversityCollege StationUSA

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