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Multidrug-Resistant Pseudomonas Infections: Hard to Treat, But Hope on the Horizon?

  • Lynn Nguyen
  • Joshua Garcia
  • Katherine Gruenberg
  • Conan MacDougall
Antimicrobial Development and Drug Resistance (A Pakyz, Section Editor)
  • 527 Downloads
Part of the following topical collections:
  1. Topical Collection on Antimicrobial Development and Drug Resistance

Abstract

Purpose of Review

As the sixth most common nosocomial pathogen in the USA, Pseudomonas aeruginosa poses a significant threat to patients within the healthcare system. Its intrinsic and acquired resistance mechanisms also significantly limit the choices for antimicrobial therapy, prompting an increase in the research and development of antibacterial agents with enhanced activity against multidrug-resistant (MDR) P. aeruginosa. While many approved and pipeline antibiotics have activity against wild-type P. aeruginosa, only four new antibiotics have promising activity against MDR P. aeruginosa: ceftazidime-avibactam (Avycaz®), ceftolozane-tazobactam (Zerbaxa®), cefiderocol, and imipenem-cilastatin/relebactam. The goal of this paper is to review the epidemiology and mechanisms of resistance in P. aeruginosa as well as explore the newly approved and pipeline agents that overcome these mechanisms of resistance.

Recent Findings

Ceftazidime-avibactam and ceftolozane-tazobactam are currently FDA-approved and available for use, while cefiderocol and imipenem-cilastatin/relebactam are in development. Current evidence suggests ceftazidime-avibactam and ceftolozane-tazobactam both may have a role in treatment of MDR P. aeruginosa infections. Ceftolozane-tazobactam appears to be modestly more potent against P. aeruginosa, but emergence of resistance has been noted in various reported cases. Trials are ongoing for cefiderocol and imipenem-cilastatin/relebactam and early results appear promising.

Summary

The aforementioned agents fill important gaps in the antibiotic armamentarium, particularly for patients with MDR P. aeruginosa infections who otherwise have extremely limited and often toxic antibiotic options. However, resistance to all of these agents will likely emerge, and additional antibiotic development is warranted to provide sufficient options to successfully manage MDR P. aeruginosa infections.

Keywords

Pseudomonas aeruginosa Antimicrobial resistance Multidrug resistant Treatment Newly approved agents Pipeline antibiotics 

Notes

Compliance with Ethical Standards

Conflict of Interest

Lynn Nguyen, Joshua Garcia, and Katherine Gruenberg declare that they have no conflict of interest. Conan MacDougall has received honoraria as a consultant for Shionogi Ltd. and grants from Merck & Co.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Lynn Nguyen
    • 1
  • Joshua Garcia
    • 2
  • Katherine Gruenberg
    • 1
  • Conan MacDougall
    • 1
  1. 1.Department of Clinical PharmacyUniversity of California San Francisco School of PharmacySan FranciscoUSA
  2. 2.Department of Pharmacy PracticeMarshall B. Ketchum University College of PharmacyFullertonUSA

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