Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria

  • Elizabeth Ann Misch
  • Christopher Saddler
  • James Muse Davis
Skin, Soft Tissue, Bone and Joint Infections (N Safdar and A Pop-Vicas, Section Editors)
  • 161 Downloads
Part of the following topical collections:
  1. Topical Collection on Skin, Soft Tissue, Bone and Joint Infections

Abstract

Purpose of Review

This review describes recent trends in the epidemiology of nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM pathogenesis, and advances in diagnosis and treatment.

Recent Findings

Emerging pathogens include Mycobacterium chimaera and drug-resistant subspecies of Mycobacterium abscessus. Important virulence mechanisms of pathogenic NTM include the ability to alter the macrophage’s permissiveness to intracellular bacterial growth. New diagnostic tools consist of DNA probes, gene sequencing, and matrix-assisted laser desorption ionization-time of flight. These methods allow rapid speciation of NTM species, in some cases directly from patient samples. There are few novel agents available to treat NTM, although some repurposed drugs show excellent activity.

Summary

The incidence of NTM infections appears to be increasing in a number of regions around the world. Molecular methods are now the diagnostic tools of choice. Discovery of novel effective agents and/or drug combinations with greater likelihood of cure, shorter treatment duration, and fewer side effects are research priorities.

Keywords

Nontuberculous mycobacteria M. chimaera Skin and soft tissue Rapidly growing mycobacteria (RGM) Molecular diagnostics 

Notes

Compliance with Ethical Standards

Conflict of Interest

Each author reports no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Elizabeth Ann Misch
    • 1
  • Christopher Saddler
    • 2
  • James Muse Davis
    • 3
  1. 1.Division of Allergy and Infectious Disease, Department of Medicine, School of Medicine and Public HealthUniversity of WisconsinMadisonUSA
  2. 2.Division of Allergy and Infectious Disease, Department of Medicine, School of Medicine and Public HealthUniversity of WisconsinMadisonUSA
  3. 3.Division of Infectious Disease, Department of Pediatrics, School of Medicine and Public HealthUniversity of WisconsinMadisonUSA

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