Neurological Presentation of Zika Virus Infection Beyond the Perinatal Period

  • Thomas De Broucker
  • Alexandra Mailles
  • Jean-Paul Stahl
Central Nervous System Infections (K Bloch, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Central Nervous System Infections

Abstract

Purpose of Review

Our purpose was to summarize the current knowledge about the neurological presentation of Zika virus infection after the perinatal period. Other Flaviviruses infections, such as West Nile virus (WNV) or Japanese encephalitis virus (JEV), can result in neuro-invasive disease such as myelitis, encephalitis, or meningitis. We aimed at describing the specificities of ZV neurological infection.

Recent Findings

The recent outbreaks demonstrated clearly the neurotropism of ZV. However, by contrast with other Flaviviruses, the most frequent neurological presentation of ZV infection beyond the perinatal period was Guillain-Barré syndrome, especially the demyelination form of GBS. Encephalitis and myelitis seem to occur less frequently after ZV infection than after WNV or JEV infection.

Summary

The pathophysiology of neurological ZV infections is still poorly understood and no specific treatment is available. Moreover, no data is available about long-term persisting symptoms and possible impairment of patients after the acute clinical episode.

Keywords

Zika Arbovirus Guillain-Barré syndrome Encephalitis Myelitis Acute disseminated encephalomyelitis (ADEM) 

Notes

Compliance with Ethical Standards

Conflict of Interest

Drs De Broucker, Mailles, and Stahl declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Thomas De Broucker
    • 1
  • Alexandra Mailles
    • 2
  • Jean-Paul Stahl
    • 3
  1. 1.NeurologyCentre Hospitalier de Saint-DenisSaint-DenisFrance
  2. 2.Santé Publique FranceSaint-MauriceFrance
  3. 3.Infectious Diseases and Tropical MedicineUniversity hospitalGrenobleFrance

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