Clinical Impact of Non-Congenital Zika Virus Infection in Infants and Children

Tropical, Travel and Emerging Infections (L Chen, Section Editor)
First Online:
Part of the following topical collections:
  1. Topical Collection on Tropical, Travel and Emerging Infections

Abstract

Purpose of Review

While the Zika virus (ZIKV) has been noted for its distinct neurotropism and identified as a significant cause for a congenital infection syndrome, there has been increased recognition of the importance to better understand the clinical impact of non-congenital ZIKV infection in infants and children. This article reviews reports of perinatal and breast milk transmission of ZIKV and summarizes current clinical outcome data of pediatric non-congenital ZIKV infection.

Recent Findings

Perinatal transmission and presence of infective ZIKV particles in breast milk have been reported. Most symptomatic non-congenital ZIKV infection in infants and children is mild and self-limited, but long-term follow-up studies are lacking.

Summary

The mechanism and impact of perinatal and breast milk transmission is unclear. The current WHO infant feeding guidelines in areas of ZIKV transmission support breastfeeding. Unless any scientific data raise concern regarding transmission via breastfeeding, the current guidelines should continue to be followed. Prospective population-based cohort studies to investigate maternal, perinatal, infant, and child outcomes are needed.

Keywords

Zika Children Non-congenital Perinatal Breast milk Complications 
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Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Hagmann declares no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Division of Pediatric Infectious DiseasesSteven and Alexandra Cohen Children’s Medical Center, Northwell HealthNew Hyde ParkUSA

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