Current Infectious Disease Reports

, Volume 15, Issue 5, pp 364–371

Noncanonical Nuclear Factor Kappa B (NF-κB) Signaling and Potential for Therapeutics in Sepsis

Sepsis and ICU (J Russell, Section Editor)


NF-κB signaling plays a central role in the pathophysiology of severe sepsis and septic shock. Despite tremendous and missed efforts, novel therapeutics for severe sepsis and septic shock are still needed. Many drugs have been designed to target the canonical NF-κB signaling pathway with limited success, potentially due to the nonspecificity of the drugs for other kinases and the interaction of canonical signaling with other pathways. Here, we review the canonical and noncanonical signaling pathways of NF-κB, the cross talk and negative regulation of the two pathways, and the potential for therapeutics arising from the noncanonical NF-κB pathway in relation to the pathophysiology of septic shock.


Sepsis Septic shock Therapeutics Noncanonical NF-κB signaling Personalized medicine 


Papers of particular interest have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.University of British Columbia, Heart Lung Innovation Research Centre, Critical Care Research LaboratoriesSt. Paul’s HospitalVancouverCanada

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