Current Infectious Disease Reports

, Volume 15, Issue 2, pp 148–157 | Cite as

Could Vitamin D Have a Potential Anti-Inflammatory and Anti-Infective Role in Bronchiectasis?

  • Jim Bartley
  • Jeff Garrett
  • Cameron C. Grant
  • Carlos A. CamargoJr
RESPIRATORY INFECTIONS (F ARNOLD, SECTION EDITOR)

Abstract

Bronchiectasis is a chronic infective and inflammatory respiratory disease that causes significant morbidity and mortality. Patients with non-cystic-fibrosis bronchiectasis are frequently vitamin D deficient, and vitamin D levels correlate with disease severity. Infection-specific actions of vitamin D include the enhancement of innate immunity and the moderation of inflammation caused by the adaptive immune response. Potentially, vitamin D could influence the processes that lead to bronchiectasis and the frequency and severity of acute exacerbations. Randomized trials of vitamin D supplementation have shown effects that are likely to be protective against the development of bronchiectasis. Several issues need to be clarified before the development of clinical trials to investigate the role of vitamin D in bronchiectasis. These include an optimal vitamin D supplementation dose and appropriate and sensitive outcome measures that include assessment of exacerbation frequency and severity, lung function, and health-related quality of life.

Keywords

Bronchiectasis Inflammation Obstructive lung disease Pathophysiology Pathology Vitamin D Innate immunity Adaptive immunity Antimicrobial peptides Chronic rhinosinusitis Microbiotia 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jim Bartley
    • 1
  • Jeff Garrett
    • 2
  • Cameron C. Grant
    • 3
  • Carlos A. CamargoJr
    • 4
  1. 1.Department of SurgeryUniversity of AucklandAucklandNew Zealand
  2. 2.Department of MedicineUniversity of AucklandAucklandNew Zealand
  3. 3.Department of Paediatrics and Centre for Longitudinal Research—He Ara ki Mua, University of Auckland & Starship Children’s Hospital, Auckland District Health Board, Auckland City HospitalAucklandNew Zealand
  4. 4.Department of Emergency MedicineMassachusetts General HospitalBostonUSA

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