Current Infectious Disease Reports

, Volume 13, Issue 2, pp 196–204

Gonococcal Resistance: Are Cephalosporins Next?

  • Robert D. Kirkcaldy
  • Ronald C. Ballard
  • Deborah Dowell
Article

DOI: 10.1007/s11908-011-0169-9

Cite this article as:
Kirkcaldy, R.D., Ballard, R.C. & Dowell, D. Curr Infect Dis Rep (2011) 13: 196. doi:10.1007/s11908-011-0169-9

Abstract

The development of resistance to multiple antibiotics has limited treatment options for gonorrhea in many countries. Currently, the Centers for Disease Control and Prevention only recommend cephalosporin antibiotics for treatment of uncomplicated gonorrhea. Although the cephalosporins remain effective, the demonstrated ability of Neisseria gonorrhoeae to develop resistance has raised concerns about the possibility of multidrug-resistant N. gonorrhoeae strains, which include cephalosporin resistance. This article provides a review of global trends in cephalosporin susceptibility among gonococcal isolates, recent findings that deepen our understanding of genetic mechanisms of resistance, and the public health and clinical implications of the potential emergence of cephalosporin-resistant gonorrhea.

Keywords

Gonorrhea Neisseria gonorrhoeae Drug resistance Cephalosporin resistance 

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2011

Authors and Affiliations

  • Robert D. Kirkcaldy
    • 1
  • Ronald C. Ballard
    • 1
  • Deborah Dowell
    • 1
  1. 1.Division of STD Prevention, National Center for HIV, Hepatitis, STD, and TB PreventionCenters for Disease Control and PreventionAtlantaUSA

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