Current Infectious Disease Reports

, Volume 13, Issue 1, pp 83–93 | Cite as

The Rapidly Evolving Research on Vitamin D Among HIV-Infected Populations

  • Edgar Turner OvertonEmail author
  • Michael T. Yin


With ongoing improvement in antiretroviral therapy, mortality among HIV-infected persons has dramatically decreased. For HIV-infected persons who remain engaged in care on suppressive therapy, life expectancy approaches that of the general population. Additionally, we have seen increases in comorbidities traditionally associated with aging: diabetes, hypertension, dyslipidemia, ischemic heart disease, and osteoporosis. Vitamin D deficiency has also been identified as a highly prevalent entity among HIV-infected populations. The association of vitamin D deficiency with several of these comorbidities and its impact on immune function provide the impetus for well-designed studies to evaluate the impact of vitamin D supplementation on HIV disease and antiretroviral therapy. This review summarizes the role of vitamin D in several disease states that are prevalent among HIV populations, with a specific focus on bone health and the interactions with antiretroviral medications.


HIV AIDS Vitamin D Bone health 



Conflicts of interest: E. Overton—grants from the Centers for Disease Control and Prevention, National Institutes of Health, GlaxoSmithKline, Tibotec, and Gilead, and honoraria from Boehringer Ingelheim, Bristol-Meyers Squibb, GlaxoSmithKline/Viiv, Tibotec, Gilead, Merck, and Monogram Sciences; M. Yin—grants from the National Institutes of Health, Gilead, and Bristol-Meyers Squibb, and honoraria from Gilead.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Infectious DiseasesWashington University School of MedicineSt. LouisUSA
  2. 2.Division of Infectious DiseasesColumbia University Medical CenterNew YorkUSA

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