Current Infectious Disease Reports

, Volume 12, Issue 3, pp 198–203 | Cite as

Pulmonary Nontuberculous Mycobacterial Disease: New Insights into Risk Factors for Susceptibility, Epidemiology, and Approaches to Management in Immunocompetent and Immunocompromised Patients

Article

Abstract

Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and cause a wide range of diseases in humans. Pulmonary involvement, the most common disease manifestation of NTM infection, is being increasingly encountered in clinical settings. In addition, specific phenotypic and genetic characteristics of persons predisposed to contract pulmonary NTM disease are now beginning to be recognized. Prior to treatment, patients should meet clinical and microbiologic criteria for NTM disease. Treatment involves prolonged courses of antibiotics in various combination regimens that are often discontinued because of serious side effects. In some cases, complete cure of pulmonary disease is difficult to achieve. Rather, clinical improvement may be a more feasible goal. Surgical treatment is warranted for select patients.

Keywords

Nontuberculous mycobacteria Bronchiectasis Mycobacterium avium complex Mycobacterium abscessus Mycobacterium kansasii Cystic fibrosis 

Notes

Disclosure

This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health.

The views expressed in this article are those of the authors and do not necessarily reflect those of the US Department of Health and Human Services.

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Copyright information

© US Government 2010

Authors and Affiliations

  1. 1.Immunopathogenesis SectionLaboratory of Clinical Infectious Diseases/NIAIDBethesdaUSA

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