Current Infectious Disease Reports

, Volume 12, Issue 2, pp 103–109

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS): a Controversial Diagnosis

  • Sheila Knupp Feitosa de Oliveira
  • Christina Feitosa Pelajo

DOI: 10.1007/s11908-010-0082-7

Cite this article as:
de Oliveira, S.K.F. & Pelajo, C.F. Curr Infect Dis Rep (2010) 12: 103. doi:10.1007/s11908-010-0082-7


Despite more than a decade of studying pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS), it is still not possible to confirm its existence and whether it is a poststreptococcal autoimmune disorder. Many controversies remain: the diagnostic criteria have not been validated, evidence of autoimmunity remains inconclusive, evidence of a genetic predisposition is weak, and streptococcal infections are common in childhood and could represent only a trigger of exacerbations of tics and obsessive-compulsive disorder. Patients who fit the PANDAS criteria appear to represent a subgroup of children with chronic tic disorder and/or obsessive-compulsive disorder who may experience symptom exacerbations after group A β-hemolytic streptococci infections; however, those infections are not the sole or even the most common antecedent of exacerbations. There is not enough evidence to support PANDAS as a unique clinical entity.


PANDAS Streptococcus Tics Obsessive compulsive disorder Autoimmunity 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Sheila Knupp Feitosa de Oliveira
    • 1
  • Christina Feitosa Pelajo
    • 2
  1. 1.Division of Pediatric Rheumatology, Instituto de Puericultura e Pediatria Martagão GesteiraUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  2. 2.Division of Pediatric RheumatologyFloating Hospital for Children at Tufts Medical CenterBostonUSA

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