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Current Infectious Disease Reports

, Volume 11, Issue 1, pp 40–50 | Cite as

Tick-borne rickettsioses in America: Unanswered questions and emerging diseases

  • Philippe Parola
  • Marcelo B. Labruna
  • Didier RaoultEmail author
Article

Abstract

During most of the 20th century, Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, was considered the only tick-borne rickettsia associated with human diseases in the Americas. This dogma suggested that the other characterized and noncharacterized rickettsiae isolated from ticks were not pathogenic to humans. This concept has been modified extensively in the past 10 years with the identification of at least three additional rickettsial species that cause human tick-borne rickettsioses and that are prevalent in the Americas, including Rickettsia parkeri, Rickettsia massiliae, and Rickettsia africae. Moreover, the genetic variability of R. rickettsii and the milder forms of Rocky Mountain spotted fever reactivate the hypothesis that some circulating genotypes of R. rickettsii may be more virulent than others and may explain the wide variations in fatality rates of the disease.

Keywords

Emerg Infect Spotted Fever Spotted Fever Group Rickettsial Disease Rocky Mountain Spotted Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References and Recommended Reading

  1. 1.
    Parola P, Paddock C, Raoult D: Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin Microbiol Rev 2005, 18:719–756.PubMedCrossRefGoogle Scholar
  2. 2.
    Childs JE, Paddock C: Rocky Mountain spotted fever. In Rickettsial Diseases. Edited by Raoult D, Parola P. New York: Informa Healthcare; 2007:97–116.Google Scholar
  3. 3.
    Paddock CD, Sumner JW, Comer JA, et al.: Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. Clin Infect Dis 2004, 38:805–811.PubMedCrossRefGoogle Scholar
  4. 4.
    Vitale G, Mansuelo S, Rolain JM, Raoult D: Rickettsia massiliae human isolation. Emerg Infect Dis 2006, 12:174–175.PubMedGoogle Scholar
  5. 5.
    Eremeeva ME, Bosserman EA, Demma LJ, et al.: Isolation and identification of Rickettsia massiliae from Rhipicephalus sanguineus ticks collected in Arizona. App Environ Microbiol 2006, 72:5569–5577.CrossRefGoogle Scholar
  6. 6.
    Cicuttin GL, Rodriguez Vargas M, Jado I, Anda P: Primera detección de Rickettsia massiliae en la ciudad de Buenos Aires, resultados preliminares. Rev Argentina Zoonosis 2004, 1:10.Google Scholar
  7. 7.
    Kelly PJ: Rickettsia africae in the West Indies. Emerg Infect Dis 2006, 12:224–226.PubMedGoogle Scholar
  8. 8.
    Raoult D, Fournier PE, Eremeeva M, et al.: Naming of Rickettsiae and rickettsial diseases. Ann N Y Acad Sci 2005, 1063:1–12.PubMedCrossRefGoogle Scholar
  9. 9.
    Chapman AS, Bakken JS, Folk SM, et al.: Tickborne Rickettsial Working Group: Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis—United States: a practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep 2006, 55:1–27.Google Scholar
  10. 10.
    Dantas-Torres F: Rocky Mountain spotted fever. Lancet Infect Dis 2007, 7:724–732.PubMedCrossRefGoogle Scholar
  11. 11.
    Raoult D, Parola P: Rickettsial Diseases. New York: Informa Healthcare; 2007.Google Scholar
  12. 12.
    Demma LJ, Traeger MS, Nicholson WL, et al.: Rocky Mountain spotted fever in Arizona associated with an unexpected tick vector. N Engl J Med 2005, 353:587–594.PubMedCrossRefGoogle Scholar
  13. 13.
    Wikswo ME, Hu R, Metzger ME, Eremeeva ME: Detection of Rickettsia rickettsii and Bartonella henselae in Rhipicephalus sanguineus ticks from California. J Med Entomol 2007, 44:158–162.PubMedCrossRefGoogle Scholar
  14. 14.
    Paddock CD, Fernandez S, Echenique GA, et al.: Rocky mountain spotted fever in Argentina. Am J Trop Med Hyg 2008, 78:687–692.PubMedGoogle Scholar
  15. 15.
    Hidalgo M, Orejuela L, Fuya P, et al.: Rocky Mountain spotted fever, Colombia. Emerg Infect Dis 2007, 13:1058–1060.PubMedGoogle Scholar
  16. 16.
    Estripeaut D, Aramburú MG, Sáez-Llorens X, et al.: Rocky Mountain spotted fever, Panama. Emerg Infect Dis 2007, 13:1763–1765.PubMedGoogle Scholar
  17. 17.
    Pinter A, Labruna MB: Isolation of Rickettsia rickettsii and Rickettsia bellii in cell culture from the tick Amblyomma aureolatum in Brazil. Ann N Y Acad Sci 2006, 1078:523–529.PubMedCrossRefGoogle Scholar
  18. 18.
    Fuentes L, Calderón A, Hun L: Isolation and identification of Rickettsia rickettsii from the rabbit tick (Haemaphysalis leporispalustris) in the Atlantic Zone of Costa Rica. Am J Trop Med Hyg 1985, 34:564–567.PubMedGoogle Scholar
  19. 19.
    Calic SB, Barcellos-Rocha CM, Leite RC, et al.: Old and new human rickettsiosis in Minas Gerais state, Brazil. Ann N Y Acad Sci 2005, 1063:356–357.PubMedCrossRefGoogle Scholar
  20. 20.
    Gehrke FS, Mendes do Nascimento EM, Rodrigues de Souza E, et al.: Detection of Rickettsia rickettsii and Rickettsia sp. in blood clots in 24 patients from different municipalities of the State of Sao Paulo, Brazil. Ann N Y Acad Sci 2006, 1078:260–262.PubMedCrossRefGoogle Scholar
  21. 21.
    Angerami RN, Resende MR, Feltrin AFC, et al.: Brazilian spotted fever: a case series from an endemic area in southeastern Brazil. Ann N Y Acad Sci 2006, 1078:170–172.PubMedCrossRefGoogle Scholar
  22. 22.
    Zavala-Castro JE, Zavala-Velázquez JE, Walker DH, et al.: Fatal human infection with Rickettsia rickettsii, Yucatán, Mexico. Emerg Infect Dis 2006, 12:672–674.PubMedGoogle Scholar
  23. 23.
    Guedes E, Leite RC, Prata MC, et al.: Detection of Rickettsia rickettsii in the tick Amblyomma cajennense in a new Brazilian spotted fever-endemic area in the state of Minas Gerais. Mem Inst Oswaldo Cruz 2005, 100:841–845.PubMedCrossRefGoogle Scholar
  24. 24.
    Labruna MB, Pacheco RC, Richtzenhain LJ, Szabo MP: Isolation of Rickettsia rhipicephali and Rickettsia bellii from ticks Haemaphysalis juxtakochi in the state of Sao Paulo, Brazil. Appl Environ Microbiol 2007, 73:869–873.PubMedCrossRefGoogle Scholar
  25. 25.
    Labruna MB, Pacheco RC, Nava S, et al.: Infection by Rickettsia bellii and Candidatus ‘Rickettsia amblyommii’ in Amblyomma neumanni ticks from Argentina. Microb Ecol 2007, 54:126–133.PubMedCrossRefGoogle Scholar
  26. 26.
    Chapman AS, Murphy SM, Demma LJ, et al.: Rocky Mountain spotted fever in the United States, 1997–2002. Vector Borne Zoonotic Dis 2006, 6:170–178.PubMedCrossRefGoogle Scholar
  27. 27.
    McNabb SJ, Jajosky RA, Hall-Baker PA, et al.: Centers for Disease Control and Prevention: Summary of notifiable diseases—United States, 2006. MMWR Morbidity and Mortality Weekly Report 2008, 55(53):1–92. Available at http://www.cdc.gov/mmwr/PDF/wk/mm5553.pdf. Accessed May 26, 2008.Google Scholar
  28. 28.
    Cunha BA: Clinical features of Rocky Mountain spotted fever. Lancet Infect Dis 2008, 8:143–144.PubMedCrossRefGoogle Scholar
  29. 29.
    Raoult D, Paddock CD: Rickettsia parkeri and other spotted fever infections in the United States. N Engl J Med 2005, 353:626–627.PubMedCrossRefGoogle Scholar
  30. 30.
    Wilson LB, Chowning WM: Studies in Pyroplasmosis hominis (“spotted fever” or “tick fever” of the Rocky Mountains). J Infect Dis 1904, 1:31–57.Google Scholar
  31. 31.
    Ormsbee RA: A review: “Studies in Pyroplasmosis hominis (‘spotted fever’ or ‘tick fever’ of the Rocky Mountains)” by Louis B. Wison and William M. Chowning. Rev Infect Dis 1979, 1:559–562.PubMedGoogle Scholar
  32. 32.
    Philip RN: Rocky Mountain Spotted Fever in Western Montana. Hamilton, MT: The Bitter Root Historical Society; 2000.Google Scholar
  33. 33.
    Rucker WC: Rocky Mountain spotted fever. Pub Health Rep 1912, 27:1465–1482.Google Scholar
  34. 34.
    Parker RR: Rocky Mountain spotted fever. J Am Med Assoc 1938, 110:1185–1188.Google Scholar
  35. 35.
    McDade JE: Evidence supporting the hypothesis that rickettsial virulence factors determine the severity of spotted fever and typhus group infections. Ann N Y Acad Sci 1990, 590:20–26.PubMedCrossRefGoogle Scholar
  36. 36.
    Anacker RL, McCaul TF, Burgdorfer W, Gerloff RK: Properties of selected rickettsiae of the spotted fever group. Infect Immun 1980, 27:468–474.PubMedGoogle Scholar
  37. 37.
    Anacker RL, Philip RN, Williams JC, et al.: Biochemical and immunochemical analysis of Rickettsia rickettsii strains of various degrees of virulence. Infect Immun 1984, 44:559–564.PubMedGoogle Scholar
  38. 38.
    Karpathy SE, Dasch GA, Eremeeva ME: Molecular typing of isolates of Rickettsia rickettsii by use of DNA sequencing of variable intergenic regions. J Clin Microbiol 2007, 45:2545–2553.PubMedCrossRefGoogle Scholar
  39. 39.
    Galvao MA, Dumler JS, Calic SB, et al.: Fatal spotted fever rickettsiosis, Minas Gerais, Brazil. Emerg Infect Dis 2003, 9:1402–1405.PubMedGoogle Scholar
  40. 40.
    Whitman TJ, Richards AL, Paddock CD, et al.: Rickettsia parkeri infection after tick bite, Virginia. Emerg Infect Dis 2007, 13:334–336. http://www.cdc.gov/EID/content/13/2/334.htm.PubMedGoogle Scholar
  41. 41.
    Ralph D, Pretzman C, Daugherty N, Poetter K: Genetic relationships among the members of the family Rickettsiaceae as shown by DNA restriction fragment polymorphism analysis. Ann N Y Acad Sci 1990, 590:541–552.PubMedCrossRefGoogle Scholar
  42. 42.
    Estrada-Peña A, Venzal JM, Mangold AJ, et al.: The Amblyomma maculatum Koch, 1844 (Acari: Ixodidae: Amblyomminae) tick group: diagnostic characters, description of the larva of A. parvitarsum Neumann, 1901, 16S rDNA sequences, distribution and hosts. Syst Parasitol 2005, 60:99–112.PubMedCrossRefGoogle Scholar
  43. 43.
    Guglielmone AA, Beati L, Barros-Battesti DM, et al.: Ticks (Ixodidae) on humans in South America. Exp Appl Acarol 2006, 40:83–100.PubMedCrossRefGoogle Scholar
  44. 44.
    Sanguioni LA, Horta MC, Vianna MCB, et al.: Rickettsial infections in animals and Brazilian spotted fever endemicity. Emerg Infect Dis 2005, 11:265–270.Google Scholar
  45. 45.
    Goddard J: Experimental infection of lone star ticks, Amblyomma americanum (L.), with Rickettsia parkeri and exposure of guinea pigs to the agent. J Med Entomol 2003, 40:686–689.PubMedGoogle Scholar
  46. 46.
    Matsumoto K, Brouqui P, Raoult D, Parola P: Transmission of Rickettsia massiliae in the tick, Rhipicephalus turanicus. Med Vet Entomol 2005, 19:263–270.PubMedCrossRefGoogle Scholar
  47. 47.
    Parola P, Jourdan J, Raoult D: Tick-borne infection caused by Rickettsia africae in the West Indies. N Engl J Med 1998, 338:1391.PubMedCrossRefGoogle Scholar
  48. 48.
    Parola P, Vestris G, Martinez D, et al.: Tick-borne rickettiosis in Guadeloupe, the French West Indies: isolation of Rickettsia africae from Amblyomma variegatum ticks and serosurvey in humans, cattle, and goats. Am J Trop Med Hyg 1999, 60:888–893.PubMedGoogle Scholar
  49. 49.
    Raoult D, Fournier PE, Fenollar F, et al.: Rickettsia africae, a tick-borne pathogen in travelers to sub-Saharan Africa. N Engl J Med 2001, 344:1504–1510.PubMedCrossRefGoogle Scholar
  50. 50.
    Conti-Diaz IA, Rubio I, Somma Moreira RE, Perez Bormida G: Rickettsiosis cutaneo ganglionar por Rickettsia conorii en el Uruguay. Rev Inst Med Trop Sao Paulo 1990, 32:313–318.PubMedGoogle Scholar
  51. 51.
    Diaz IA: Rickettsiosis caused by Rickettsia conorii in Uruguay. Ann N Y Acad Sci 2003, 990:264–266.PubMedCrossRefGoogle Scholar
  52. 52.
    Venzal JM, Portillo A, Estrada-Pena A, et al.: Rickettsia parkeri in Amblyomma triste from Uruguay. Emerg Infect Dis 2004, 10:1493–1495.PubMedGoogle Scholar
  53. 53.
    Billings AN, Yu XJ, Teel FD, Walker DH: Detection of a spotted fever group rickettsia in Amblyomma cajennense (Acari: Ixodidae) in south Texas. J Med Entomol 1998, 35:474–478.PubMedGoogle Scholar
  54. 54.
    Mediannikov O, Paddock C, Parola P: Other rickettsiae of possible or undeterminde pathogenicity. In Rickettsial Diseases. Edited by Raoult D, Parola P. New York: Informa Healthcare; 2007:163–177.Google Scholar
  55. 55.
    Billeter SA, Blanton HL, Little SE, et al.: Detection of Rickettsia amblyommii in association with a tick bite rash. Vector Borne Zoonotic Dis 2007, 7:607–610.PubMedCrossRefGoogle Scholar
  56. 56.
    Apperson CS, Engber B, Nicholson WL, et al.: Tick-borne diseases in North Carolina: is “Rickettsia amblyommii” a possible cause of rickettsiosis reported as Rocky Mountain Spotted Fever? Vector Borne Zoonotic Dis 2008 (Epub ahead of print).Google Scholar
  57. 57.
    Sumner JW, Durden LA, Goddard J, et al.: Gulf Coast ticks (Amblyomma maculatum) and Rickettsia parkeri, United States. Emerg Infect Dis 2007, 13:751–753. http://www.cdc.gov/EID/content/13/5/751.htm.PubMedGoogle Scholar
  58. 58.
    Labruna MB, Whitworth T, Bouyer DH, et al.: Rickettsia bellii and Rickettsia amblyommii in Amblyomma ticks from the state of Rondonia, Western Amazon, Brazil. J Med Entomol 2004, 41:1073–1081.PubMedCrossRefGoogle Scholar
  59. 59.
    Paddock CD, Finley RW, Wright CS, et al.: Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever. Clin Infect Dis 2008, 47:1188–1196.PubMedCrossRefGoogle Scholar

Copyright information

© Current Medicine Group LLC 2009

Authors and Affiliations

  • Philippe Parola
  • Marcelo B. Labruna
  • Didier Raoult
    • 1
    Email author
  1. 1.Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS-IRD 6236World Health Organization Collaborative Center for Rickettsial and Other Arthropod-Borne Bacterial Diseases, Faculté de MédecineMarseille Cedex 5France

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