Current Infectious Disease Reports

, Volume 9, Issue 5, pp 382–386 | Cite as

Long-term outcomes from sepsis

Article

Abstract

Long-term mortality following severe sepsis is high, and fewer than half of patients who experience severe sepsis are alive at 1 year. Mechanisms underlying increased long-term mortality remain poorly understood. Animal and human studies suggest that abnormalities of the innate immune system may contribute to increased long-term mortality. This review article examines the epidemiology and potential mechanisms underlying long-term outcomes from sepsis and challenges to conducting long-term outcome studies in the critically ill.

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Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Department of Critical Care MedicineUniversity of PittsburghPittsburghUSA

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