Arterial Stiffness and Coronary Ischemia: New Aspects and Paradigms

  • Alexandre ValléeEmail author
  • Alexandre Cinaud
  • Athanase Protogerou
  • Yi Zhang
  • Jirar Topouchian
  • Michel E. Safar
  • Jacques Blacher
Blood Pressure Monitoring and Management (J Cockcroft, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Blood Pressure Monitoring and Management


Purpose of Review

Aortic stiffness (AS) is widely associated with hypertension and considered as a major predictor of coronary heart disease (CHD). AS is measured using carotid–femoral pulse wave velocity (PWV), particularly when this parameter is associated with an index involving age, gender, heart rate, and mean blood pressure. The present review focuses on the interest of measurement of PWV and the calculation of individual PWV index for the prediction of CHD, in addition with the use of new statistical nonlinear models enabling results with very high levels of accuracy.

Recent Findings

PWV index may so constitute a substantial marker of large arteries prediction and damage in CHD and may be also used in cerebrovascular and renal circulations models. PWV index determinations are particularly relevant to consider in angiographic CHD decisions and in the presence of vulnerable plaques with high cardiovascular risk. Due to the variability in symptoms and clinical characteristics of patients, together with some imperfections in results, there is no very simple adequate diagnosis approach enabling to improve the so defined CHD prediction in usual clinical practice.


In recent works in relation to “artificial intelligence” and involving “decision tree” models and “artificial neural networks,” it has been possible to determine consistent pathways introducing predictive medicine and enabling to obtain efficient algorithm classification models of coronary prediction.


Coronary heart disease Artificial intelligence Data mining Pulse wave velocity Aortic stiffness Personalized medicine 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Alexandre Vallée
    • 1
    Email author
  • Alexandre Cinaud
    • 1
  • Athanase Protogerou
    • 2
  • Yi Zhang
    • 3
  • Jirar Topouchian
    • 1
  • Michel E. Safar
    • 1
  • Jacques Blacher
    • 1
  1. 1.Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu HospitalParis-Descartes UniversityParisFrance
  2. 2.Cardiovascular Prevention and Research Unit, Department of PathophysiologyNational and Kapodistrian University of AthensAthensGreece
  3. 3.Department of Cardiology, Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina

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