Current Hypertension Reports

, 21:70 | Cite as

Blood Pressure and Statin Effects on Cognition: a Review

  • Mia YangEmail author
  • Jeff Williamson
Secondary Hypertension: Nervous System Mechanisms (M Wyss, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Secondary Hypertension: Nervous System Mechanisms


Purpose of Review

This is a review of available data on the effects of blood pressure and statins on cognition.

Recent Findings

Recent randomized clinical trials have shown that intensive control of systolic blood pressure in older adults prevented the development of mild cognitive impairment (MCI) and the combined effects of MCI and probable dementia. Previous randomized clinical trials have suggested that statin use may prevent a decline in cognition; however, no randomized clinical trials have clearly shown evidence of statin’s either positive or negative effect on cognition.


Continued follow-up of SPRINT-MIND participants is crucial to evaluate the long-term effects of intensive systolic blood pressure control on the prevention of cognitive decline. A well-conducted and adequately powered randomized control trial is needed to evaluate the effect of statins on cognition, especially for primary prevention of the cognitive decline in aging.


Blood pressure Statin Hypertension Cognition Cognitive impairment Dementia 


Compliance with Ethical Standards

Conflict of Interest

Dr. Williamson reports grants from the National Institutes of Health, during the conduct of the study; Dr. Yang declares no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Department of Internal Medicine, Section on Gerontology & Geriatric MedicineWake Forest School of MedicineWinston-SalemUSA

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