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The Na+K+-ATPase Inhibitor Marinobufagenin and Early Cardiovascular Risk in Humans: a Review of Recent Evidence

  • Michél Strauss
  • Wayne Smith
  • Olga V. Fedorova
  • Aletta E. SchutteEmail author
Secondary Hypertension: Nervous System Mechanisms (Michael Wyss, Section Editor)
  • 35 Downloads
Part of the following topical collections:
  1. Topical Collection on Secondary Hypertension: Nervous System Mechanisms

Abstract

Purpose of Review

This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na+/K+-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular risk markers.

Recent Findings

Twenty-four-hour urinary MBG strongly associates with habitual salt intake in young healthy adults (aged 20–30 years). Furthermore, in young healthy adults free of detected cardiovascular disease, MBG associates with increased large artery stiffness and left ventricular mass independent of blood pressure. These findings in human studies corroborate mechanistic data from rat studies whereby stimulation of MBG by a high salt intake or MBG infusion increased vascular fibrosis and cardiac hypertrophy.

Summary

Twenty-four-hour urinary MBG may be a potential biomarker of early cardiovascular risk. Adverse associations between MBG—which increases with salt consumption—and early cardiovascular risk markers support the global efforts to reduce population-wide salt intake in an effort to prevent and control the burden of non-communicable diseases.

Keywords

Early cardiovascular risk Humans Marinobufagenin Women Salt-sensitivity 

Notes

Funding

The sources of funding of this research are the South African Medical Research Council (SAMRC), the South African Research Chairs Initiative (SARChI) of the Department of Science and Technology, and National Research Foundation (NRF) of South Africa (UID 86895 and 111862). This research was supported in part by the Intramural research Program of the NIH, National Institute on Aging, Baltimore, Maryland, USA.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Ethical Considerations

This manuscript does not contain patient data.

Disclaimer

Any opinion, findings, and conclusions or recommendations expressed in this material are those of the authors, and therefore, the NRF does not accept any liability in regard.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Michél Strauss
    • 1
  • Wayne Smith
    • 1
    • 2
  • Olga V. Fedorova
    • 3
  • Aletta E. Schutte
    • 1
    • 2
    Email author
  1. 1.Hypertension in Africa Research Team (HART)North-West UniversityPotchefstroomSouth Africa
  2. 2.MRC Research Unit: Hypertension and Cardiovascular DiseaseNorth-West UniversityPotchefstroomSouth Africa
  3. 3.Laboratory of Cardiovascular ScienceNational Institute on Aging, NIHBaltimoreUSA

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