Epicardial Adipose Tissue and Cardiovascular Disease

  • Thierry H. Le JemtelEmail author
  • Rohan Samson
  • Karnika Ayinapudi
  • Twinkle Singh
  • Suzanne Oparil
Hypertension and Obesity (E Reisin, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Hypertension and Obesity


Purpose of Review

Epicardial adipose tissue has been associated with the development/progression of cardiovascular disease. We appraise the strength of the association between epicardial adipose tissue and development/progression of cardiovascular diseases like coronary artery disease, atrial fibrillation, and heart failure with preserved ejection fraction.

Recent Findings

Cross-sectional clinical and translational correlative studies have established an association between epicardial adipose tissue and progression of coronary artery disease. Recent studies question this association and underline the need for longitudinal studies. Epicardial adipose tissue also plays a definite role in the pathobiology of atrial fibrillation and its recurrence after ablation. In contrast to an early paradigm, epicardial adipose tissue does not appear to play a key role in the pathogenesis of heart failure with preserved ejection fraction in obese patients.


The association of epicardial adipose tissue with atrial fibrillation is robust. In contrast, the association of epicardial adipose tissue with coronary artery disease and heart failure with preserved ejection fraction is tenuous. Additional research, including longitudinal studies, is needed to confirm or refute these proposed associations.


Epicardial adipose tissue Coronary artery disease Atrial fibrillation Heart failure with preserved ejection fraction 


Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Thierry H. Le Jemtel
    • 1
    Email author
  • Rohan Samson
    • 1
  • Karnika Ayinapudi
    • 1
  • Twinkle Singh
    • 1
  • Suzanne Oparil
    • 2
  1. 1.Section of Cardiology, Department of MedicineTulane University School of Medicine; Tulane University Heart and Vascular InstituteNew OrleansUSA
  2. 2.Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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