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Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis

  • Larissa Marques Santana
  • Lisiane Perin
  • Rosana Lunelli
  • José Francisco Secorun Inácio
  • Clarissa Garcia Rodrigues
  • Bruna Eibel
  • Silvia GoldmeierEmail author
Guidelines/Clinical Trials/Meta-Analysis (William J. Kostis, Section Editor)
  • 35 Downloads
Part of the following topical collections:
  1. Topical Collection on Guidelines/Clinical Trials/Meta-Analysis

Abstract

Purpose of Review

We aimed to evaluate the prevalence of sexual dysfunction in hypertensive women and compare sexual dysfunction between hypertensive and non-hypertensive women.

Recent Findings

Conducted a systematic review in the following databases: PubMed, EMBASE, Scopus, Web of Science, IBECS, and Lilacs.

We included articles evaluating the prevalence of sexual dysfunction in a woman and/or comparing sexual dysfunction between hypertensive and non-hypertensive women. Studies were excluded if they evaluated patients with secondary hypertension, examined sexual dysfunction caused by drugs, did not distinguish by gender, or included patients with hypertension and other comorbidities/pathologies.

We conducted an I2 test to calculate heterogeneity and a meta-analysis to compare sexual dysfunction between hypertensive and non-hypertensive women. A meta-regression equation calculated the relationship between sexual dysfunction risk for hypertensive and age.

Eleven articles were included: five were included in the meta-analysis (1057 hypertensive and 715 normotensive). The prevalence of sexual dysfunction in articles varied from 14.1 to 90.1%. In the meta-analysis of the sexual dysfunction, the relative risk between hypertensive and normotensive women was found to be significant and has a high heterogeneity (I2 =92.6%, p < 0.001); the pooled results revealed a significant risk ratio of 1.81 (95% CI 1.10–2.97, p < 0.05). The relative risk for hypertensive women showed an association with age (b = 0.0333, p < 0.0001).

Summary

The studies analyzed presented significant limitations in relation to methodology and a small sample size. Consequently, the meta-analysis was highly heterogeneous and reinforced the need for further research in this area.

Keywords

Hypertension Systolic Meta-analysis Women Sexuality Sexual dysfunctions Psychological 

Notes

Acknowledgements

We would like to thank the Instituto de Cardiologia do RS—Fundação Universitária de Cardiologia (IC-FUC) for assistance in developing the study.

Availability of Data and Material

It registered in the Prospero (International Prospective Register of Systematic Reviews) database under the number CRD42014008704.

Authors’ Contributions

S.M.L and P.L conceived the study, participated in the study design, and helped to draft the manuscript; I.S.F.J, L.R, R.G.C, and G.S participated in the study design and coordination, undertook data analysis, and helped to draft the manuscript; E.B and G.S participated in the study design and coordination. All authors read and approved the final manuscript.

Funding

This study was financially supported by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Ethics Approval and Consent to Participate

No. 4512/10.

Consent for Publication

Ethical approval was obtained from the Ethical Committee, Foundation University of Cardiology for conducting the research study.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Larissa Marques Santana
    • 1
  • Lisiane Perin
    • 2
  • Rosana Lunelli
    • 2
  • José Francisco Secorun Inácio
    • 2
  • Clarissa Garcia Rodrigues
    • 2
  • Bruna Eibel
    • 2
  • Silvia Goldmeier
    • 2
    Email author
  1. 1.Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA)Porto AlegreBrazil
  2. 2.Instituto de Cardiologia do RS – Fundação Universitária de Cardiologia (IC-FUC)Porto AlegreBrazil

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