Personalized Medicine and the Treatment of Hypertension
Purpose of Review
The purpose of this review is to discuss the implications of personalized medicine for the treatment of hypertension, including resistant hypertension.
We suggest a framework for the personalized treatment of hypertension based on the concept of a trade-off between simplicity and personalization. This framework is based on treatment strategies classified as low, medium, or high information burden personalization approaches. The extent to which a higher information burden is justified depends on the clinical scenario, particularly the ease with which the blood pressure can be controlled.
A one-size-fits-many treatment strategy for hypertension is efficacious for most people; however, a more personalized approach could be useful in patients with subtypes of hypertension that do not respond as expected to treatment. Clinicians seeing patients with unusual hypertension phenotypes should be familiar with emerging trends in personalized treatment of hypertension.
KeywordsPersonalized medicine Population health Blood pressure Hypertension Resistant hypertension Primary aldosteronism
The authors are appreciative of engaging discussions on the topic with Dr. Martin MacKinnon, Department of Nephrology and his Complicated Hypertension Clinic nurse, Shelley Nairn, both of the Saint John Regional Hospital, and Translational Scientist, Dr. Keith Brunt. SM appreciates the professional and financial support provided by the New Brunswick Health Research Foundation (NBHRF) via grants to Dr. Keith R. Brunt and Dr. Sohrab Lutchmedial.
Compliance with Ethical Standards
Conflict of Interest
SM has no conflict of interest to declare and is supported via funding from the New Brunswick Health Research Foundation (NBHRF) (Operating Grant: Health Research Value Demonstration Initiative [HRVDI]) provided directly to professional supervisors, Keith R. Brunt, PhD (IMPART investigator team Canada) and Sohrab Lutchmedial, MD, FRCP(C) (CardioVascular Research New Brunswick, Saint John Regional Hospital, Horizon Health Network). JBB is funded by the National Institutes of Health award 5K23HL128909.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
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