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Obesity and Pulmonary Hypertension

  • Karnika Ayinapudi
  • Twinkle Singh
  • Ayush Motwani
  • Thierry H. Le Jemtel
  • Suzanne Oparil
Hypertension and Obesity (E Reisin, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Hypertension and Obesity

Abstract

Purpose of Review

Whether the present obesity epidemic will increase the prevalence of pulmonary hypertension over the next decades is unclear. We review the obesity-related mechanisms that may further the development and progression of pulmonary hypertension.

Recent Findings

Systemic and local inflammation, insulin resistance and oxidative stress contribute to the pathobiology of obesity and pulmonary arterial hypertension. Preliminary data suggest that expansion of adipose tissue surrounding the pulmonary artery may hasten the progression of pulmonary arterial hypertension in obese persons. Further, obesity-associated cardiac and pulmonary conditions may increase the prevalence of groups 2 and 3 pulmonary hypertension.

Summary

The obesity epidemic is likely to increase the prevalence of pulmonary arterial hypertension by enabling vascular remodeling. Obesity-associated cardiac and pulmonary conditions will increase pulmonary hypertension prevalence.

Keywords

Obesity Pulmonary hypertension Perivascular adipose tissue 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Karnika Ayinapudi
    • 1
  • Twinkle Singh
    • 1
  • Ayush Motwani
    • 1
  • Thierry H. Le Jemtel
    • 1
  • Suzanne Oparil
    • 2
  1. 1.Tulane University Heart and Vascular InstituteNew OrleansUSA
  2. 2.Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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